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HGF — TP53
Text-mined interactions from Literome
Inoue et al., Hepatology 2002
:
In conclusion,
p53 production is
stimulated by
HGF and may contribute to the proliferation of rat hepatocytes
Chen et al., Bone 2011
:
Transfection of siRNA specific for cMet, the HGF receptor, eliminated the HGF anti-proliferation effect on hMSCs and the
HGF mediated increase in
p53 , p21, and p27, strongly supporting a role for these cell-cycle inhibitors in HGF 's regulation of hMSCs
Iwabayashi et al., Biochem Biophys Res Commun 2012
(Atherosclerosis...) :
On the other hand,
HGF significantly
attenuated EPC dysfunction, senescence, ROS production, and
p53 and p21 expression induced by Lp(a)
Metcalfe et al., Nucleic Acids Res 1997
:
Our results show that wild-type but not mutant
p53 activates the
HGF/SF promoter when using -3000 and -755 bp upstream of the HGF/SF gene ... We propose that the
HGF/SF promoter can be
activated by wild-type
p53 in vivo and that this could be as a result of a novel form of sequence-specific DNA binding