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BAIAP2 — WASF2

Pathways - manually collected, often from reviews:

• KEGG Adherens junction: RAC1/RAC2/RAC3 → Complex of BAIAP2-WASF1-WASF2-WASF3 (protein-protein, activation)
  
• KEGG Adherens junction: Complex of BAIAP2-WASF1-WASF2-WASF3 → ACTB/ACTG1 (protein-protein, activation)
• KEGG Regulation of actin cytoskeleton: BAIAP2 → WASF2 (protein-protein, activation)
• Reactome Reaction: WASF2 → BAIAP2 (indirect_complex) Leng et al., Proc Natl Acad Sci U S A 2005, Suetsugu et al., J Cell Biol 2006, Nakanishi et al., J Biochem 2007, Mendoza et al., Mol Cell 2011, Miki et al., EMBO J 1998
• Reactome Reaction: WASF2 → BAIAP2 (reaction) Suetsugu et al., J Cell Biol 2006, Miki et al., EMBO J 1998
• WikiPathways Regulation of Actin Cytoskeleton: BAIAP2 → WASF2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WASF2 — BAIAP2 (direct interaction, pull down) Miki et al., Nature 2000*
• IRef Biogrid Interaction: WASF2 — BAIAP2 (direct interaction, far western blotting) Miki et al., Nature 2000*
• IRef Intact Interaction: BAIAP2 — WASF2 (physical association, pull down) Miki et al., Nature 2000*
• IRef Intact Interaction: BAIAP2 — WASF2 (physical association, anti tag coimmunoprecipitation) Miki et al., Nature 2000*
• IRef Intact Interaction: BAIAP2 — WASF2 (physical association, far western blotting) Miki et al., Nature 2000*
• IRef Ophid Interaction: BAIAP2 — WASF2 (aggregation, confirmational text mining) Miki et al., Nature 2000*
• IRef Ophid Interaction: BAIAP2 — WASF2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Suetsugu et al., J Cell Biol 2006 : When we measured Arp2/3 activation in vitro, the WAVE2 complex isolated from the membrane fraction of cells was fully active in an IRSp53 dependent manner but WAVE2 isolated from the cytosol was not ... Purified WAVE2 and purified WAVE2 complex were activated by IRSp53 in a Rac dependent manner with PIP ( 3 ) -containing liposomes
Abou-Kheir et al., J Cell Sci 2008 : Membrane targeting of WAVE2 is not sufficient for WAVE2 dependent actin polymerization : a role for IRSp53 in mediating the interaction between Rac and WAVE2 ... Importantly, reduction of endogenous IRSp53 or expression of IRSp53 lacking the WAVE2 binding site ( IRSp53DeltaSH3 ) resulted in a significant reduction in the association of Rac1 with WAVE2 and Abi1, indicating that the association of Rac1 with WAVE2 and Abi1 is IRSp53 dependent
Takahashi et al., Cell Signal 2010 : Suppression of IRSp53 expression by two independent small interfering RNAs ( siRNAs ) completely inhibited IGF-I induced membrane targeting and local accumulation of WAVE2 at the leading edge of cells