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RELA — SFN
Text-mined interactions from Literome
Heiss et al., J Biol Chem 2001
:
SFN selectively
reduced DNA binding of
NF-kappa B without interfering with LPS induced degradation of the inhibitor of NF-kappa B nor with nuclear translocation of NF-kappa B
Choi et al., Carcinogenesis 2007
(Prostatic Neoplasms) :
The
effect of
SFN on levels of IAP family proteins as well as transcriptional activity of
NFkappaB was biphasic in LNCaP cells
Moon et al., Cancer Lett 2009
(Neoplasms) :
We also report that
SFN non-specifically
inhibited TNF-alpha induced
NF-kappaB activation through the inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, and p65 nuclear translocation ... These effects suggest that
SFN inhibits TNF-alpha induced
NF-kappaB activation through the suppression of IkappaBalpha degradation, leading to reduced expression of NF-kappaB regulated gene products ... In conclusion, the results of the present study indicate that
SFN suppresses TNF-alpha induced
NF-kappaB activity and induces apoptosis through activation of ROS dependent caspase-3
Youn et al., J Immunol 2010
:
SFN formed adducts with cysteine residues in the extracellular domain of TLR4 as confirmed by liquid chromatography-tandem mass spectrometry analysis and the inhibitory
effects of
SFN on oligomerization and
NF-kappaB activation were reversed by thiol donors ( DTT and N-acetyl-L-cysteine )