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MT3 — RELA
Text-mined interactions from Literome
Sakurai et al., FEBS Lett 1999
:
Regulatory
role of
metallothionein in
NF-kappaB activation
Hinata et al., Oncogene 2003
(Inflammation) :
Levels of
growth inhibitory factor (GIF) , in contrast, were
increased by
NF-kappa B in both settings but inhibited growth only in keratinocytes
Butcher et al., J Pharmacol Exp Ther 2004
:
In fact, MT-KO cells had higher nuclear levels of NF-KappaB p65 than did MT-WT cells, despite a lower cellular NF-KappaB level and function, suggesting that
metallothionein mediated the specific activity of
NF-KappaB ... These data support the hypothesis that
metallothionein positively
regulates the cellular level and activity of
NF-KappaB
Kim et al., Toxicological sciences : an official journal of the Society of Toxicology 2009
:
The
MT-III induced antiapoptotic effects and increase in
NF-kappaB activity were blocked by specific inhibitors of TrkA, phosphatidylinositol-3 kinase (PI3K), Akt, or NF-kappaB, indicating that MT-III provides neuronal protection by activating NF-kappaB through the TrkA/PI3K/Akt signaling pathway