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NFKB1 — TNFRSF1B

Text-mined interactions from Literome

Hamanoue et al., Mol Cell Neurosci 1999 : p75 mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor
Pimentel-Muiños et al., Immunity 1999 : In the presence of RIP, TNFR2 triggers cell death, whereas in the absence of RIP, TNFR2 activates NF-kappaB
Foehr et al., J Neurosci 2000 : Although both p75 and TrkA activated nuclear factor-kappaB (NF-kappaB) , we show that distinct proximal signaling intermediates are used by each receptor ... Blocking p75 mediated activation of NF-kappaB by ecdysone-inducible expression of a nondegradable mutant of IkappaBalpha significantly enhanced apoptosis
Okada et al., Cytokine 2001 : TNFR2 blockade suppressed NFkappaB1 and FLIP expression and increased cell death
Youn et al., Immunol Lett 2002 (Arthritis, Rheumatoid...) : This TNF-alpha induced proliferation of synoviocytes obtained from RA patients coincided with down-regulation of TNFR1 and up-regulation of TNFR2 and TRAF1-6, as well as NF-kappaB activation
Roux et al., Prog Neurobiol 2002 : p75NTR has been shown to activate the NF-kappaB , Akt, and JNK pathways and interacts with several adaptor proteins
Kotani et al., Shock 2003 (Inflammation) : TNFR-1 ( p55 ) and Fas share a death domain which is critical for apoptosis signaling whereas TNFR-p55 and TNFR-2 ( p75 ) can activate NF-kappaB leading to anti-apoptotic proteins expression such as A1
Burke et al., J Neurobiol 2003 : p75 neurotrophin receptor mediates neurotrophin activation of NF-kappa B and induction of iNOS expression in P19 neurons
Maeda et al., Immunity 2003 : While TNFR2 does not contribute to NF-kappaB activation, it is important for ConA induced JNK activation, which is augmented by the absence of IKKbeta
Marchetti et al., J Biol Chem 2004 : Both TNFR1 and TNFR2 induced the NF-kappa B pathway, yet with distinguishable kinetics and upstream activating components, TNFR1 only induced transient NF-kappa B activation, whereas TNFR2 facilitated long term phosphatidylinositol 3-kinase dependent NF-kappa B activation strictly ... Glutamate induced triggering of the ionotropic N-methyl-D-aspartate receptor was required for the enhanced and persistent phosphatidylinositol 3-kinase dependent NF-kappa B activation by TNFR2 , indicating a positive cooperation of TNF and neurotransmitter induced signal pathways ... TNFR2 induced persistent NF-kappa B activity was essential for neuronal survival
Till et al., J Biol Chem 2005 : Albeit the mutation does not affect the TNF binding kinetics of TNFR2, the present study provides evidence that the mutation results in a significantly lower capability to induce TNFR2 mediated NF-kappaB activation
Thommesen et al., J Biochem Mol Biol 2005 (Colonic Neoplasms) : The TNFR1 response was inhibited by D609, bromophenacyl bromide ( BPB ), nordihydroguararetic acid ( NDGA ), and by sodium salicylate, while TNFR2 mediated activation of NFkappaB and CMV promoter-enhancer was resistant to these compounds
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)1, TNFR2 , NF-kappaB inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB
Jin et al., Mol Cancer Res 2007 (Neoplasm Invasiveness...) : Further studies showed that p75NTR could suppress the nuclear factor-kappaB (NF-kappaB) signal
Al-Lamki et al., J Am Soc Nephrol 2008 (Nephritis) : Inhibition of NF-kappaB activation increased TL1A mediated caspase-3 activation and apoptosis of TEC, but it did not reduce the induction of TNFR2
Carpentier et al., Biochem Biophys Res Commun 2008 : This was associated with enhanced TNF-R2 induced JNK activation, whereas TNF-R2 induced NF-kappaB activation remained unaffected
Hamid et al., Circulation 2009 (Cardiomegaly...) : In H9c2 cardiomyocytes, sustained NF-kappaB activation was proapoptotic, an effect dependent on TNFR1 signaling, whereas TNFR2 overexpression attenuated TNF induced NF-kappaB activation
Wicovsky et al., Oncogene 2009 : It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1 induced activation of NFkappaB and JNK
Al-Lamki et al., Am J Pathol 2010 (Carcinoma, Renal Cell) : R2-TNF increases TNFR2 , activates NF-kappaB , Etk, and VEGFR2 and increases entry into the cell cycle
Rothe et al., Science 1995 : A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40
Laegreid et al., J Biol Chem 1994 : It was found that cross linking of TNFR p75 led to strong induction of the human cytomegalovirus enhancer as well as activation of nuclear factor-kappa B (NF-kappa B)
Brink et al., J Biol Chem 1998 : Tumor necrosis factor receptor (TNFR) associated factor 2A ( TRAF2A ), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2 mediated NF-kappaB activation ... Also in contrast to TRAF2, TRAF2A is unable to stimulate NF-kappaB activity when overexpressed in 293 cells and acts as a dominant inhibitor of TNFR2 dependent NF-kappaB activation
Ng et al., Biochem Biophys Res Commun 1998 : In addition, the x1c domain is also crucial for TNFR2 mediated NF-kappa B activation
Yamada et al., Hepatology 1998 : Lack of TNFR-2 had little effect on NF-kappaB and STAT3 binding, and no effect in interleukin-6 production after PH, but caused a delay in AP-1 and C/EBP binding and in the expression of c-jun and c-myc messenger RNA ( mRNA ) ... We conclude that TNFR-1, but not TNFR-2 , is necessary for liver regeneration, and that NF-kappaB and STAT3 binding are activated by signals transduced by TNFR-1