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NFKB1 — S100A6

Text-mined interactions from Literome

Joo et al., Biochem Biophys Res Commun 2003 (Hepatoblastoma...) : Involvement of NF-kappaB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2 ... Transient expression of NF-kappaB ( p65 ) increased S100A6 promoter activity and expression of inhibitor of NF-kappaB ( IkappaBalpha ) decreased TNFalpha induced S100A6 promoter activity ... To confirm the involvement of NF-kappaB in S100A6 promoter activation, we analyzed serially deleted promoter constructs of the S100A6 gene by luciferase reporter assay and found a NF-kappaB-responsive DNA fragment at the position between -584 and -361
Tsoporis et al., J Biol Chem 2008 (Inflammation) : These results demonstrate that S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation