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NFKB1 — NOD2

Text-mined interactions from Literome

Hugot et al., Nature 2001 (Colitis, Ulcerative...) : NOD2 activates nuclear factor NF-kB ; this activating function is regulated by the carboxy-terminal leucine-rich repeat domain, which has an inhibitory role and also acts as an intracellular receptor for components of microbial pathogens
Ogura et al., Nature 2001 (Crohn Disease...) : Wild-type NOD2 activates nuclear factor NF-kappaB , making it responsive to bacterial lipopolysaccharides ; however, this induction was deficient in mutant NOD2
Gutierrez et al., J Biol Chem 2002 (Crohn Disease...) : Nod2 , a member of the Apaf1/Nod protein family, confers responsiveness to bacterial products and activates NF-kappaB , a transcription factor that plays a central role in innate immunity
Sen et al., J Immunol 2003 (Diabetes Mellitus, Type 1) : Furthermore, increased NF-kappaB activation resulted in an enhanced capacity of NOD vs NOR or BALB/c Mphi to secrete IL-12 ( p70 ), TNF-alpha, and IL-1alpha, which was inhibited upon infection with an adenoviral recombinant encoding a modified form of IkappaBalpha
Ogura et al., Genomics 2003 (Crohn Disease) : Expression of mouse Nod2 activated NF-kappaB and conferred responsiveness to bacterial components, an activity that was deficient in mutants corresponding to those associated with susceptibility to Crohn 's disease
Iwanaga et al., Inflamm Res 2003 (Arthritis...) : Expression of mouse NOD2 into HEK cells resulted in NF-kappaB activation
Hugot et al., Eur J Gastroenterol Hepatol 2003 (Crohn Disease...) : Because CARD15 is able to be activated by components of the bacterial wall and further induce the activation of NFkappaB , a proinflammatory molecule, CARD15 discovery makes the link, at the molecular level, between bacteria and inflammation of the digestive tract
Chen et al., J Biol Chem 2004 (Crohn Disease) : In this study, we determined that mitogen activated protein kinase kinase transforming growth factor ( TGF)-beta activated kinase 1 (TAK1 ) interacts with Nod2 and is required for Nod2 mediated NF-kappaB activation ... Nod2 , acting in a reciprocal manner, inhibited TAK1 induced NF-kappaB activation in RICK-deficient embryonic fibroblasts
Damiano et al., Biochem J 2004 : NF-kappaB ( nuclear factor kappaB ) reporter assays demonstrated that co-expression of either full-length CLAN or the NACHT domain of CLAN significantly inhibited NF-kappaB activation induced by Nod1 or Nod2 overexpression
Opitz et al., J Biol Chem 2004 : By dominant negative overexpression and small interfering RNA experiments, we show for the first time that interleukin-1 receptor associated kinase participates in Nod2 dependent NF-kappaB activation ... Additionally, dominant negative interleukin-1 receptor associated kinase 2, tumor necrosis factor receptor associated factor 6, NF-kappaB inducing kinase, transforming growth factor-beta activated kinase binding protein 2, and transforming growth factor-beta activated kinase 1 also inhibited Nod2 dependent NF-kappaB activation ... Furthermore, Rip-2 and members of the Toll-like receptor signaling cascade are involved in the Nod2 dependent activation of NF-kappaB induced by pneumococci
Watanabe et al., Nat Immunol 2004 (Crohn Disease) : Moreover, NOD2 deficiency or the presence of a Crohn disease-like Card15 mutation increased Toll-like receptor 2-mediated activation of NF-kappa B-c-Rel , and T ( H ) 1 responses were enhanced
Opitz et al., Circ Res 2005 : In conclusion, we demonstrated that C pneumoniae induced a Nod1 mediated and Nod2 mediated NF-kappaB activation in HEK293 cells
Linderson et al., Int J Colorectal Dis 2005 (Crohn Disease...) : We sought to determine whether CARD15 mediated NF-kappaB activation can contribute to MDP induced TNFalpha production and, consequently, if polymorphisms in both genes affect the control of such induction ... Transfection and electrophoretic mobility shift assays ( EMSA ) experiments in HEK293 cells demonstrated that MDP exposure stimulates TNFalpha gene transcription, as a result of CARD15 induced NF-kappaB activation and binding to TNFalpha promoter
McDonald et al., J Biol Chem 2005 (Inflammation...) : A role for Erbin in the regulation of Nod2 dependent NF-kappaB signaling ... We found that Nod2 dependent activation of NF-kappaB and cytokine secretion is inhibited by Erbin overexpression, whereas Erbin-/- mouse embryo fibroblasts show an increased sensitivity to muramyl dipeptide
Charrier et al., Lab Invest 2006 (Inflammation...) : The small bacterial peptides subsequently induce an inflammatory response, including the induction of MHC class I molecules expression and cytokines secretion, via the activation of nucleotide binding site and leucine-rich repeat ( NBS-LRR ) proteins, for example NOD2 , and activation of NF-kappaB
Kufer et al., Infect Immun 2006 : Furthermore, ectopic expression of increasing amounts of Erbin or short hairpin RNA mediated knockdown of Erbin showed a negative influence of Erbin on Nod2/muramyl-dipeptide mediated NF-kappaB activation
Rosenstiel et al., Cell Microbiol 2006 (Chronic Disease...) : Expression of NOD1 and NOD2 significantly sensitized HEK293 cells to H. pylori induced NF-kappaB activation in a cag pathogenicity island ( cagPAI ) -dependent manner
Yamamoto-Furusho et al., J Biol Chem 2006 : Functionally, CENTB1 overexpression inhibited NOD1- and NOD2 dependent activation of NF-kappaB , whereas small inhibitory RNA against CENTB1 increased NF-kappaB activation following NOD1- or NOD2 mediated recognition of the bacterial components gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively
Wolfert et al., Infect Immun 2007 : The compounds that induced synergistic effects were also able to activate NF-kappaB in a NOD1- or NOD2 dependent manner, implicating these proteins in synergistic TNF-alpha secretion
Legrand-Poels et al., J Cell Sci 2007 : Modulation of Nod2 dependent NF-kappaB signaling by the actin cytoskeleton ... We showed that actin disruption by CytD significantly and specifically increased Nod2 mediated NF-kappaB signaling ... Membrane ruffle disruption by a Rac1 dominant negative form primed Nod2 dependent NF-kappaB signaling ... The recruitment of Nod2 in Rac induced dynamic cytoskeletal structures could be a strategy to both repress the Nod2 dependent NF-kappaB signaling in unstimulated cells and rapidly mobilize Nod2 during bacterial infection
Sebban-Benin et al., Hum Mol Genet 2007 (Incontinentia Pigmenti) : Mutation of all these ubiquitination sites severely impaired NF-kappaB activation induced by stimulation with IL-1, LPS, Nod2/RICK or serum/LPA
Yang et al., J Biol Chem 2007 (Tuberculosis) : We find Rip2 required for Nod2 mediated NF-kappaB activation and to a lesser extent mitogen activated protein kinase activation ... We also demonstrate a requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6, and the ubiquitin activated kinase Tak1 in Nod2 mediated NF-kappaB activation
Kim et al., J Biol Chem 2008 : We found that TAK1 deletion completely abolished MDP-NOD2 signaling, activation of NF-kappaB and MAPKs, and subsequent induction of cytokines/chemokines in keratinocytes
Hasegawa et al., EMBO J 2008 : A critical role of RICK/RIP2 polyubiquitination in Nod induced NF-kappaB activation ... Nod1 and Nod2 stimulation activates NF-kappaB through RICK, a caspase-recruitment domain containing kinase ... However, the mechanism by which RICK activates NF-kappaB in response to Nod1 and Nod2 stimulation is unknown ... Thus, RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2 mediated NF-kappaB activation
Dufner et al., Mol Cell Biol 2008 : RIP2 mediates NF-kappaB activation induced by the intracellular nucleotide binding oligomerization domain ( NOD ) receptors that sense bacterial peptidoglycan
Shaw et al., Curr Opin Immunol 2008 : Stimulation of NOD1 and NOD2 , two prototypic NLRs, results in the activation of MAPK and NF-kappaB
Mulla et al., Am J Reprod Immunol 2009 : In addition, Nod1 and Nod2 mRNA expression was upregulated following treatment of trophoblast cells with lipopolysaccharide (LPS), and this was significantly reduced by the presence of a NFkappaB inhibitor and a TLR4-dominant negative ( DN )
Zucchelli et al., Inflamm Bowel Dis 2009 (Colitis, Ulcerative...) : An in vitro system was set up to evaluate the potential impact of SLC15A1 polymorphism on PepT1 transporter function by quantification of NOD2 mediated activation of NF-kappaB
Lin et al., J Endod 2009 : The interaction of NOD2 with downstream signaling molecules ultimately results in the activation of NF-kappaB and production of inflammatory mediators in innate immunity
Bielig et al., Mol Immunol 2009 : A function for AAMP in Nod2 mediated NF-kappaB activation
Yamamoto-Furusho et al., Inflamm Bowel Dis 2010 (Salmonella Infections) : HNP-1 is required for NOD2 dependent NF-kappaB activation after MDP-LD stimulation since hnp-1 siRNA transfection abrogated the response to MDP-LD stimulation
Liu et al., Proc Natl Acad Sci U S A 2010 (Helicobacter Infections) : Together these observations indicate that OLFM4 exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization
Rogler et al., J Crohns Colitis 2007 : Taken together these data indicate that NOD2 mediated NF-kappaB activation, subsequent induction of anti-microbial peptides such as defensins and induction of cytokine expression are essential for the function of the intestinal barrier and for the prevention of bacterial translocation
Lappas et al., Biol Reprod 2013 : Agonist activation of NOD1 and NOD2 by bacterial products leads to NFKB activation and transcription of NFKB induced prolabor genes