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FOSL1 — JUND

Pathways - manually collected, often from reviews:

• FastForward regulation: JUND → FOSL1 (transcriptional regulation, unknown) Adiseshaiah et al., J Biol Chem 2003*
  Evidence: DNABINDING
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) → Involucrin (IVL) (transcription, activates) Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008, Welter et al., J Biol Chem 1995
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1 (FOSL1) → JUND (JUND) (modification, collaborate) Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1 (FOSL1) → Fra1/JUND complex (FOSL1-JUND) (modification, collaborate)
  Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: JUND (JUND) → Fra1/JUND complex (FOSL1-JUND) (modification, collaborate)
  Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: JUND (JUND) → Fra1 (FOSL1) (modification, collaborate) Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: JUND (JUND) → Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) (modification, collaborate)
  Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1 (FOSL1) → Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) (modification, collaborate)
  Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: JUNB (JUNB) → Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) (modification, collaborate)
  Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: p300 (EP300) → Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) (modification, collaborate)
  Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1/p300/JUNB/JUND/SP1 complex (FOSL1-EP300-JUNB-JUND-SP1) → SP1 (SP1) (modification, collaborate) Adhikary et al., Invest Ophthalmol Vis Sci 2005, Crish et al., J Invest Dermatol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database AP-1 transcription factor network: Fra1 (FOSL1) → JUND (JUND) (modification, collaborate) Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: Fra1 (FOSL1) → Fra1/JUND complex (FOSL1-JUND) (modification, collaborate)
  Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUND (JUND) → Fra1/JUND complex (FOSL1-JUND) (modification, collaborate)
  Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: FOSL1 — JUND Newman et al., Science 2003
• IRef Bind_translation Interaction: FOSL1 — JUND (array technology) Newman et al., Science 2003
• IRef Ophid Interaction: FOSL1 — JUND (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Adiseshaiah et al., J Biol Chem 2003 : In particular, coexpression of c-Jun, Jun-D , and Fra-2 up-regulated fra-1 transcription
Tang et al., J Biol Chem 1998 : Supershift analysis demonstrated that JunD was the major moiety contributing to AP-1-DNA binding in unstimulated cells and that c-Jun-, Fra-1- , and Fra-2-DNA binding were increased whereas JunD-DNA binding was decreased in TGF-beta1 stimulated cells