UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

KDR — NRP2

Pathways - manually collected, often from reviews:

NCI Pathway Database VEGF and VEGFR signaling network: NRP2 (NRP2) → VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) (modification, collaborate)
Favier et al., Blood 2006, Xu et al., J Cell Biol 2010 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: NRP2 (NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFC (dimer) complex (VEGFC) (modification, collaborate)
Favier et al., Blood 2006, Xu et al., J Cell Biol 2010 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFC (dimer)/NRP2 complex (FLT4-KDR-VEGFC-NRP2) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006, Xu et al., J Cell Biol 2010 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (dimer)/VEGFA (dimer)/NRP2 complex (KDR-VEGFA-NRP2) → VEGFA (dimer) complex (VEGFA) (modification, collaborate)
Gluzman-Poltorak et al., J Biol Chem 2000 *, Soker et al., J Cell Biochem 2002 *, Shintani et al., EMBO J 2006 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (dimer)/VEGFA (dimer)/NRP2 complex (KDR-VEGFA-NRP2) → NRP2 (NRP2) (modification, collaborate) Gluzman-Poltorak et al., J Biol Chem 2000 *, Soker et al., J Cell Biochem 2002 *, Shintani et al., EMBO J 2006 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2 (dimer)/VEGFA (dimer)/NRP2 complex (KDR-VEGFA-NRP2) → VEGFR2 (KDR) (modification, collaborate) Gluzman-Poltorak et al., J Biol Chem 2000 *, Soker et al., J Cell Biochem 2002 *, Shintani et al., EMBO J 2006 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: NRP2 (NRP2) → VEGFR2 (KDR) (modification, collaborate) Gluzman-Poltorak et al., J Biol Chem 2000 *, Soker et al., J Cell Biochem 2002 *, Shintani et al., EMBO J 2006 *
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFA (dimer) complex (VEGFA) → VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) (modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → NRP2 (NRP2) (modification, collaborate) Favier et al., Blood 2006
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2) → VEGFR3 (FLT4) (modification, collaborate) Favier et al., Blood 2006
Evidence: physical interaction
NCI Pathway Database VEGF and VEGFR signaling network: NRP2 (NRP2) → VEGFR2 (KDR) (modification, collaborate) Favier et al., Blood 2006
Evidence: physical interaction

Text-mined interactions from Literome

Shintani et al., EMBO J 2006 : Finally, NRP1 expression and its GAG modification post-transcriptionally regulate VEGFR2 protein expression
Geretti et al., Mol Cancer Res 2010 (Melanoma) : Here, we show that MutB-NRP2 inhibited ( 125 ) I-VEGF binding to NRP1, NRP2, and VEGFR-2