Gene interactions and pathways from curated databases and text-mining

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CASP8 — PML

Text-mined interactions from Literome

Giannì et al., Leukemia 1999 (Leukemia, Promyelocytic, Acute) : In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3 mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies
Alemany et al., Leukemia & lymphoma 2000 (Leukemia, Megakaryoblastic, Acute...) : Various mechanisms have been proposed for the As2O3 induced changes in NB4 ( including modulation of promyelocytic leukemia proteins (PML) and Bcl-2, modification of the glutathione redox system, caspase activation , and cell cycle arrest ) and are currently under investigation in the megakaryocytic leukemia cell lines
Barbarroja et al., Br J Haematol 2008 (Cell Transformation, Neoplastic...) : The blockade of MEK/ERK pathway resulted in caspase dependent degradation of PML/RARalpha , and attenuation of the cell differentiation induction
Kuwayama et al., Neuro Oncol 2009 (Glioblastoma) : The overexpression of PML activated caspase-8 and induced apoptosis in GBM cells
Wang et al., Nat Genet 1998 (Leukemia, Promyelocytic, Acute) : Pml is required for caspase 1 and caspase 3 activation upon exposure to these stimuli
Mologni et al., Blood 1999 (Leukemia, Promyelocytic, Acute) : Treatment of APL cells with CD437 is associated with a caspase dependent degradation of promyelocytic leukemia-RAR-alpha , which can be completely inhibited by z-VAD