Dooms et al., J Exp Med 2007
:
Because the generation of CD4 ( + ) memory T cells is dependent on IL-7-IL-7Ralpha interactions, primed IL-2 ( -/- ) or CD25 ( -/- ) CD4 ( + ) T cells develop poorly into long lived memory cells
Kiazyk et al., Trends Microbiol 2008
(HIV Infections) :
We propose that reduced expression of CD127 ( IL-7 receptor alpha chain, IL-7Ralpha ), induced by immune activation, contributes to CD4 ( + ) T cell loss in HIV infection
Guimond et al., Nat Immunol 2009
(Lymphopenia) :
Our results indicate that IL-7Ralpha ( + ) DCs are regulators of the peripheral CD4 ( + ) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4 ( + ) T cell population expansion in vivo