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BIRC2 — CASP12

Text-mined interactions from Literome

Steinman et al., Mol Med 2000 : c-IAP1 loss involved proteasomal, rather than caspase , degradation pathways
Partheniou et al., Biochem Biophys Res Commun 2001 (Leukemia) : In contrast, there was a caspase dependent cleavage of XIAP, but not c-IAP1 , during treatment with TNFalpha for 7 days
Choi et al., Int J Oncol 2002 : Co-treatment with NAC markedly prevented dephosphorylation of Akt, activation of caspase 3, and down-regulation of cIAP1
Vaziri et al., Anticancer Res 2003 : VP-16 and KN-62 co-treatment was associated with caspase activation via the mitochondrial pathway and significant reductions ( p = 0.002 ) in c-IAP1 protein expression but not with c-IAP2 or XIAP
Zhao et al., J Toxicol Environ Health 2004 (Inflammation...) : The release of cytochrome c from mitochrondria, the activation of caspase-3 , -8, and -9, the cleavage of nuclear poly ( ADP-ribose ) polymerase ( PARP ), and the expression of TNF receptors ( TNF-R1/p55 and TNF-R2/p75 ), TNF-R associated factor 2 (TRAF2), and cellular inhibitor of apoptosis 1 ( c-IAP1 ) were determined by immunoblotting
Peng et al., J Neurosci Res 2005 (Nerve Degeneration) : Further, inhibition of cellular inhibitors of apoptosis protein 1 ( c-IAP1 ) expression by small interfering RNA ( siRNA ) increased TRAIL mediated caspase-3 activation and apoptosis ; thus, c-IAP1 protects NPCs against TRAIL induced apoptosis and suppresses caspase-3 activation
Liu et al., Mol Cancer Ther 2006 (Breast Neoplasms) : Interestingly, the nonspecific caspase inhibitor, z-VAD-FMK, inhibited the down-regulation of Akt, XIAP, and cIAP-1 in cerulenin- and LY294002 treated cells
Das et al., Cancer 2007 (Glioblastoma) : Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and activation of calpain, caspase-9 , and caspase-3
Ribeiro et al., J Cell Biol 2007 : Here, we show that Drosophila melanogaster inhibitor of apoptosis protein 2 ( DIAP2 ) controls the level of caspase activity in living cells
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Karmakar et al., Neuroscience 2009 (Body Weight...) : Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing ( BIRC ) proteins including BIRC-2 and BIRC-3, and activation of caspase-3 and apoptosis inducing factor ( AIF )
Yang et al., Cell Biol Toxicol 2010 (Carcinoma, Hepatocellular...) : Adenosine downregulated the expression of mRNAs and proteins for Bcl-X ( L ) and inhibitor of apoptosis protein 2 (IAP2) to directly inhibit caspase-3 , -7, and -9, but it otherwise upregulated the expression of mRNA and protein for DIABLO, an inhibitor of IAPs
Farhana et al., Cell Death Differ 2011 : 3-Cl-AHPC activation of the noncanonical pathway was preceded by caspase mediated decrease in the E3-ligase c-IAP1 with subsequent stabilization of NF-?B inducing kinase ( NIK ) expression, increased binding of NIK by TRAF3, activation of IKKa, and the resultant increased levels of RelB and p52