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IKBKB — IRS1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IRS1
—
IKBKB
(physical association, affinity chromatography technology)
Gao et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
IKBKB
—
IRS1
(in vivo)
Aguirre et al., J Biol Chem 2000*, Aguirre et al., J Biol Chem 2002*, Gao et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
IKBKB
—
IRS1
(in vitro)
Aguirre et al., J Biol Chem 2000*, Aguirre et al., J Biol Chem 2002*, Gao et al., J Biol Chem 2002*
-
IRef Innatedb Interaction:
IKBKB
—
IRS1
(unknown, -)
Gao et al., J Biol Chem 2002*
Text-mined interactions from Literome
Gao et al., J Biol Chem 2003
(Insulin Resistance) :
Taken together, these data suggest that serine phosphorylation of
IRS-1 in response to TNF-alpha is
mediated , in part, by JNK and
IKK
He et al., Mol Endocrinol 2006
(Insulin Resistance) :
Tyrosine phosphorylation of
IRS-1 was
recovered only by the
IKK inhibitor or JNK inhibitor, suggesting specific involvement of these two kinases