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RHOA — SRC
Pathways - manually collected, often from reviews:
-
KEGG Adherens junction:
SRC
→
RHOA
(protein-protein, inhibition)
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/RasGAP/p190RhoGAP complex (PTK2-YES1_SRC_FYN-RASA1-ARHGAP35)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Arthur et al., Curr Biol 2000, Arthur et al., Mol Biol Cell 2001, Holinstat et al., J Biol Chem 2006, Playford et al., Exp Cell Res 2008, Tomar et al., J Cell Sci 2009
Evidence: mutant phenotype, assay
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/RasGAP/p190RhoGAP complex (PTK2-YES1_SRC_FYN-RASA1-ARHGAP35)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Arthur et al., Curr Biol 2000, Arthur et al., Mol Biol Cell 2001, Holinstat et al., J Biol Chem 2006, Playford et al., Exp Cell Res 2008, Tomar et al., J Cell Sci 2009
Evidence: mutant phenotype, assay
-
Reactome Reaction:
RHOA
→
SRC
(reaction)
Wahl et al., J Cell Biol 2000, Dickson et al., Curr Opin Neurobiol 2001, Sahin et al., Neuron 2005, Le Boeuf et al., Mol Biol Cell 2006
Text-mined interactions from Literome
Arthur et al., Curr Biol 2000
:
Integrin engagement suppresses
RhoA activity via a
c-Src dependent mechanism ... Here we show that integrin engagement initially inactivates
RhoA , in a
c-Src dependent manner, but has no effect on Cdc42 or Rac1 activity
Baisden et al., Oncogene 2001
:
Lastly, dominant positive
RhoA ( V14 ) will block the ability of AFAP-110 ( Deltalzip ) from inducing actin filament rosettes, but does not
inhibit Src activation
Salsmann et al., J Biol Chem 2005
:
Finally, alphaIIbbeta3 dependent
RhoA stimulation and cell spreading, but not cell attachment, are
Src dependent and phosphoinositide 3-kinase independent and are inhibited by the Src antagonist PP2
Veettil et al., J Virol 2006
:
Inhibition of Src activation by CdTxB and reduction of RhoA activation by Src inhibitors suggest that KSHV induced
Src is
involved in
RhoA activation, which in turn is involved in a feedback sustained activation of Src
Kim et al., Small 2009
:
The results indicate that this microenvironment effect on the biphasic
RhoA activation in RMCs is
mediated by
Src and actomyosin machinery
Putnam et al., Cell communication and signaling : CCS 2009
:
Inhibition of
Src signaling was sufficient to restore normal actin architecture, and
resulted in decreased p190RhoGAP phosphorylation and enhanced
RhoA activity
Bhoopathi et al., Cell Signal 2011
(Medulloblastoma...) :
Transfection with SPARC siRNA reversed
Src mediated disruption of the cytoskeleton organization as well as dephosphorylation of cofilin and activation of
Rho A
Balanis et al., Mol Biol Cell 2011
:
Expression of an inactive ß3 integrin subunit abolishes p190RhoGAP tyrosine phosphorylation, demonstrating a mechanistic link between ß3 integrin activated
Src and EGFR
regulation of the
RhoA inhibitor
Yeh et al., PloS one 2012
:
The inhibition of
Src/Vav2 attenuated the HSG mediated
RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG
Boscher et al., Mol Biol Cell 2013
(Breast Neoplasms...) :
Direct activation of integrin with Mn ( 2+ ) induces galectin-3, ILK, and
Src dependent
RhoA activation and caveolin-1 phosphorylation
Gomes et al., PloS one 2013
:
The characterization of downstream molecular targets of c-Met activation, involved in the invasive phenotype, revealed increased phosphorylation of FAK and
Src proteins and
activation of Cdc42, Rac1 and
RhoA GTPases
Ushio-Fukai et al., Mol Pharmacol 1999
:
Thus, we provide evidence here that Gbetagamma as well as Galpha12 subunits mediate AT1 receptor coupling to tonic PLD activation via
pp60(c-src) dependent mechanisms, and that
RhoA is involved in these signaling pathways in rat VSMCs