◀ Back to IGF1
IGF1 — ITGAV
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
ITGAV
→
IGF1
(increases)
Evidence: Treatment of HT29-D4 cells with antibodies to alphaV, alpha-6 and beta-1 integrins significantly inhibited the des (1-3)-IGF1 (analogue of IGF-1) induced cell migration. Incubation with a mixture containing anti-alphaV, anti-alpha6 and anti-beta1antibodies together totally abolished migration, indicating that these integrin subunits are involved in the IGF-1 induced cell migration.
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NCI Pathway Database Integrins in angiogenesis:
IGF1 (IGF1)
→
alphav/beta3 Integrin complex (ITGAV-ITGB3)
(modification, collaborate)
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2006
Evidence: assay, physical interaction
Text-mined interactions from Literome
Imai et al., Endocrinology 1999
:
Our previous studies have shown that
IGF-I increases the affinity of the
alphaVbeta3 integrin toward ligands and that occupancy of this integrin is indispensable for IGF-I to stimulate cell migration
Maile et al., Endocrinology 2002
:
The
alphaVbeta3 integrin regulates
insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor
Maile et al., Sci Transl Med 2010
(Atherosclerosis...) :
We tested whether
alpha(V)beta(3) integrin activation was increased in diabetic animals and whether an antibody to beta ( 3 ) would
inhibit IGF-1 action and development of atherosclerosis
Doerr et al., J Biol Chem 1996
(Breast Neoplasms) :
We conclude that : 1 ) IGF-I stimulates migration of these two cell types through the IGF-I receptor ; 2 ) interaction of vitronectin with the
alpha v beta 5 integrin or collagen with the alpha 2 beta 1 integrin is
necessary for the complete
IGF-I response in MCF-7 cells, and 3 ) because migration represents an in vitro model for metastatic spread, integrins, extracellular matrix proteins, and IGF-I may play coordinated roles in the metastasis of breast cancer in vivo