Rizza et al., Lab Invest 1999
:
LPA but not phosphatidic acid dose-dependently increased E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ) cell surface expression ... The effects of both LPA and sphingosine-1-phosphate on the induction of both VCAM-1 and E-selectin expression was abolished by pretreatment with pertussis toxin suggesting that both LPA receptors in HAEC couple to a Gi pathway
Takami et al., Circulation 1998
:
We evaluated the effect of Lp(a) on the expression of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 , and E-selectin in human umbilical vein endothelial cells by a cell ELISA ... In contrast to ICAM-1, the expression of VCAM-1 and E-selectin was not significantly affected by Lp(a)