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TP53 — TP63
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TP63
—
TP53
(physical association, affinity chromatography technology)
Lu et al., J Biol Chem 2013*
-
IRef Hprd Interaction:
TP53
—
TP63
(in vivo)
Gaiddon et al., Mol Cell Biol 2001*
-
IRef Intact Interaction:
Complex of TP53-TP63-SMAD2-TP53-TP63-TP53-SMAD2-TP63-SMAD2
(physical association, anti bait coimmunoprecipitation)
Adorno et al., Cell 2009*
-
IRef Intact Interaction:
TP63
—
TP53
(physical association, anti bait coimmunoprecipitation)
Girardini et al., Cancer Cell 2011*
-
IRef Intact Interaction:
TP63
—
TP53
(physical association, anti bait coimmunoprecipitation)
Adorno et al., Cell 2009*
-
MIPS Negatome - no physical interaction between proteins Interaction:
TP53
—
TP63
(Absence of interaction, coimmunoprecipitation)
Li et al., Oncogene 2008*
Text-mined interactions from Literome
Shimada et al., Cancer Res 1999
:
We found that
p51/p63 trans
activated the previously identified
p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53
Senoo et al., Br J Cancer 2001
(Carcinoma, Squamous Cell...) :
Transient co-transfection data indicate the possibility that DeltaNp73L can inhibit
p53- , and more preferentially,
p51 mediated transactivation
Cam et al., Cancer Cell 2006
(Rhabdomyosarcoma) :
Whereas
p53 transactivates the retinoblastoma gene,
p63 and p73
induce the cyclin dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state