Gene interactions and pathways from curated databases and text-mining

◀ Back to NFKB1

NFKB1 — NFKBIB

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Algarté et al., J Virol 1999 (Respirovirus Infections) : These experiments demonstrate a major role for IkappaBalpha in the regulation of NF-kappaB induced IFN-beta gene activation and a minor role for IkappaBbeta in the activation process
Kemler et al., Glia 1999 (Brain Neoplasms...) : Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha stimulated astrocytes and in neuroblastoma cells
Díaz-Guerra et al., J Immunol 1999 : Treatment of cultured peritoneal macrophages with IFN-gamma resulted in tyrosine phosphorylation of IkappaBalpha and IkappaBbeta , NF-kappaB activation , and expression of inducible NO synthase (iNOS)
Mortellaro et al., J Immunol 1999 : PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta
Newton et al., J Biol Chem 1999 (Breast Neoplasms) : Overexpression of IkappaBalpha but not IkappaBbeta1 resulted in reduced constitutive DNA binding of NF-kappaB in MDA-MB-231 cells ... Unexpectedly, IkappaBbeta1 overexpression moderately increased 12-O-tetradecanoylphorbol-13-acetate- and interleukin-1-inducible NF-kappaB DNA binding
Hoshi et al., J Biol Chem 2000 : Western blot analysis of I-kappaBalpha and I-kappaBbeta , inhibitors of NF-kappaB , indicated that I-kappaBalpha degradation, rather than I-kappaBbeta degradation, was important in NF-kappaB activation after the stimulation of TRAP and bFGF
Stasiolek et al., J Biol Chem 2000 (Astrocytoma...) : These results suggest that IkappaB-beta contributes to persistent NFkappaB activation and NOS2 expression in glial cells, that IkappaB-beta is a stress protein inducible by hyperthermia or proteasome inhibitors, and that delayed addition of proteasome inhibitors can have stimulatory rather than inhibitory actions
Hajra et al., Proc Natl Acad Sci U S A 2000 (Arteriosclerosis) : In control C57BL/6 mice, expression levels of p65, IkappaBalpha, and IkappaBbeta were 5- to 18-fold higher in the HP region, yet NF-kappaB was activated in a minority of endothelial cells
Deng et al., J Biol Chem 2001 : Based on these results, we conclude that 2-AAF up-regulates mdr1b through the generation of ROS, activation of IKK kinase, degradation of I kappa B beta , and subsequent activation of NF-kappa B
Jaffray et al., J Gastrointest Surg 2000 (Acute Disease...) : Elastase, carboxypeptidase A, and lipase induced degradation of I kappa B-beta ( but not I kappa B-alpha ), activation of NF-kappa B , and production of TNF-alpha protein, whereas inhibition of I kappa B with pyrrolidine dithiocarbamate attenuated this response
Chakravortty et al., J Immunol 2001 : SA inhibited LPS induced NF-kappaB activation by preventing loss of IkappaB-alpha and -beta
Jiang et al., Oncogene 2001 (Adenocarcinoma...) : To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta , a specific inhibitor of NF-kappaB , in two human lung adenocarcinoma cell lines, A549 and H441 ... Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or TNF-alpha and abrogated the basal NF-kappaB activity in A549 cells
Kuo et al., Oncogene 2002 (Carcinoma, Hepatocellular) : 2-AAF activates IkappaB kinase (IKK), resulting in degradation of IkappaBbeta and activation of NF-kappaB
Mukhopadhyay et al., J Biol Chem 2002 : The impaired NF-kappaB activation in Bcr-Abl expressing cells was not due to absence of the NF-kappaB proteins p65, p50, or p100 or of IkappaBalpha or IkappaBbeta
Zingarelli et al., Shock 2002 (Shock, Septic) : These events were preceded by degradation of inhibitors kappaBalpha ( IkappaBalpha ) and kappaBI ( IkappaBbeta ), and activation of nuclear factor-kappaB (NF-kappaB) in the lung
Budde et al., Mol Biol Cell 2002 : We have found that IkappaBbeta expression is localized within the haploid spermatid stages of spermatogenesis and follows the expression of nuclear NF-kappaB
Lindgren et al., Biochem Biophys Res Commun 2003 : Taken together, our data implicate distinct roles for IkappaBalpha and IkappaBbeta in regulating various NF-kappaB activities
Chae et al., Immunopharmacol Immunotoxicol 2004 : Here, we suggest that the degradations of IkappaB alpha and IkappaB beta and the following activation of NF-kappaB are the targets of NAC and that NF-kappaB transcription factor is a pivotal clue to regulation of differentiation in TNFalpha exposed osteoblasts
Singh et al., Biochem Biophys Res Commun 2004 : We also report the involvement of IkappaB-alpha and IkappaB-beta in the persistent activation of NF-kappaB by L. donovani
Nasr et al., Oncogene 2005 (Leukemia-Lymphoma, Adult T-Cell...) : PS-341 treatment of these cells stabilized IkappaBalpha, IkappaBbeta , IkappaBvarepsilon, p21, p27 and p53 proteins and selectively inhibited Rel-A DNA binding NF-kappaB complexes
Hertlein et al., Mol Cell Biol 2005 : In contrast to the defined regulatory interplay between NF-kappaB and IkappaBalpha, much less is known regarding the regulation of IkappaBbeta by NF-kappaB
Campa et al., Inflamm Res 2005 (Inflammation) : Thus, poly I induced an increase in nuclear factor kappaB (NF-kappaB) transcriptional activity due to a long-term degradation of inhibitory NF-kappaB (IkappaB) beta while lipopolysaccharide (LPS) induced the degradation of both IkappaBalpha and IkappaBbeta
Dias et al., J Nutr 2005 (Diabetes Mellitus, Experimental) : Eight weeks later we measured TBARS and hydroperoxide initiated chemiluminescence ( QL ) in liver as markers of oxidative stress, and activities of the antioxidant enzymes catalase, superoxide dismutase ( SOD ), and glutathione peroxidase, NF-kappaB activation by an electrophoretic mobility shift assay and expression of IkappaB kinases ( IKKalpha and IKKbeta ), the inhibitor IkappaB ( IkappaBalpha and IkappaBbeta ), and iNOS by Western blot
Packham et al., Cell Death Differ 1997 : NF-kappaB activation by both pathways was persistent and due to the sequential degradation of IkappaB-alpha and IkappaB-beta
Griffin et al., Biochem J 2006 : Furthermore, in contrast with IkappaBalpha, NF-kappaB activation did not increase expression of endogenous IkappaBbeta as assessed by analysis of mRNA and protein levels
Lentsch et al., Shock 2007 (Acute Disease...) : In TK-/- mice, there was far less IkappaB-alpha and IkappaB-beta protein and greater activation of NF-kappaB
Watanabe et al., Lab Invest 2007 (Hodgkin Disease) : We also present the data that indicate the involvement of IkappaBbeta in NF-kappaB induction by topoisomerase inhibitors ... The results also indicate that IkappaBbeta is involved in NF-kappaB activation in H-RS cells and IkappaBbeta substitutes for IkappaBalpha in H-RS cells lacking wild-type IkappaBalpha
García-Román et al., Journal of carcinogenesis 2007 : We propose that during liver regeneration, the transitory stimulation of the transcription factor response, assures blockade of NF-kappaB until recovery of the total mass of the liver and the persistent NF-kappaB activation in early hepatocarcinogenesis may be due to IkappaB-beta and IkappaB-alpha degradation, mainly IkappaB-beta degradation, which contributes to gene transcription related to proliferation required for neoplastic progression
Shi et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colitis...) : The translocation of NF-kappaB was inhibited by blocking the degradation of IkappaBbeta
Morais et al., Nephrol Dial Transplant 2010 (Carcinoma, Renal Cell...) : PDTC significantly decreased RCC growth and the expression of NF-kappaB subunits ( p50, p52, c-Rel and RelB ), upstream IKK-beta and IKK-gamma, but did not induce any changes in the expression of IkappaB-alpha and IkappaB-beta
Beg et al., Genes Dev 1995 : Our results indicate that I kappa b beta , but not I kappa B alpha, is required for the signal dependent activation of NF-kappa B in fibroblasts
Good et al., J Virol 1996 : Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta
Suyang et al., Mol Cell Biol 1996 : Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B
Harhaj et al., Mol Cell Biol 1996 : Interestingly, activation of these NF-kappaB/Rel complexes by the CD28 signal is associated with the rapid degradation of both IkappaBalpha and IkappaBbeta , two major cytoplasmic inhibitors of NF-kappaB/Rel
Hauf et al., Proc Natl Acad Sci U S A 1997 (Leukemia P388...) : Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB ( RelA/p50 ) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation ... We suggest that products of the enzymatic activity of phospholipases directly interfere with host cell signal transduction pathways, thus leading to persistent NF-kappaB activation via persistent IkappaBbeta degradation
Cheshire et al., Mol Cell Biol 1997 : Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation
Chen et al., Mol Pharmacol 1997 : Transfection with a plasmid containing cDNA encoding mouse IkappaBbeta , an inhibitor of NF-kappaB , resulted in increased toxicity by menadione
Miyamoto et al., Mol Cell Biol 1998 : We observed that IkappaB beta , another NF-kappaB inhibitor , is also complexed with c-Rel but slowly degraded by a proteasome dependent process in WEHI231 cells
Attar et al., Mol Cell Biol 1998 : These results show that in nonstimulated T cells, IkappaB beta can not efficiently displace IkappaB alpha bound to RelA containing complexes and that persistent NF-kappaB activity is required for proper T-cell responses in vivo
Hehner et al., J Biol Chem 1998 : Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta
Krappmann et al., Immunobiology 1997 : Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability
Coscoy et al., Virology 1998 (Cell Transformation, Neoplastic...) : Therefore, Tax induced cell transformation in mice correlates with the degradation of IkappaB alpha and IkappaB beta and with the constitutive activation of NF-kappaB
Zen et al., Exp Cell Res 1998 : Lipopolysaccharide induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta
O'Connell et al., J Biol Chem 1998 : Phosphorylation of the IkappaB cytoplasmic inhibitors, IkappaBalpha, IkappaBbeta , and IkappaBepsilon, by these kinases triggers proteolytic degradation and the release of NF-kappaB/Rel proteins into the nucleus