Gene interactions and pathways from curated databases and text-mining

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DDIT3 — NFKB1

Text-mined interactions from Literome

Nozaki et al., Oncogene 2001 (Breast Neoplasms) : Repression of GADD153/CHOP by NF-kappaB : a possible cellular defense against endoplasmic reticulum stress induced cell death
Schapansky et al., Exp Neurol 2007 (Alzheimer Disease) : NF-kappaB activated by ER calcium release inhibits Abeta mediated expression of CHOP protein : enhancement by AD-linked mutant presenilin 1 ... Further, specific inhibition of NF-kappaB resulted in greater expression of CHOP, while activation of NF-kappaB inhibited CHOP expression
Du et al., J Immunol 2009 : CsA and FK506, as well as other UPR inducers, caused up-regulation of C/EBP family members, especially C/EBPbeta and CHOP ( C/EBP homologous protein ), and overexpression of either C/EBPbeta or CHOP significantly attenuated TNF-alpha triggered NF-kappaB activation
Shao et al., J Biol Chem 2010 : Here, we show that nuclear factor kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) signaling pathways regulate the expression of CCAAT/enhancer binding protein homologous protein ( CHOP ), which mediates endoplasmic reticulum stress induced apoptosis