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DDIT3 — NFKB1
Text-mined interactions from Literome
Nozaki et al., Oncogene 2001
(Breast Neoplasms) :
Repression of
GADD153/CHOP by
NF-kappaB : a possible cellular defense against endoplasmic reticulum stress induced cell death
Schapansky et al., Exp Neurol 2007
(Alzheimer Disease) :
NF-kappaB activated by ER calcium release
inhibits Abeta mediated expression of
CHOP protein : enhancement by AD-linked mutant presenilin 1 ... Further, specific inhibition of NF-kappaB resulted in greater expression of CHOP, while activation of
NF-kappaB inhibited
CHOP expression
Du et al., J Immunol 2009
:
CsA and FK506, as well as other UPR inducers, caused up-regulation of C/EBP family members, especially C/EBPbeta and CHOP ( C/EBP homologous protein ), and overexpression of either C/EBPbeta or
CHOP significantly
attenuated TNF-alpha triggered
NF-kappaB activation
Shao et al., J Biol Chem 2010
:
Here, we show that
nuclear factor kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) signaling pathways
regulate the expression of CCAAT/enhancer binding protein homologous protein (
CHOP ), which mediates endoplasmic reticulum stress induced apoptosis