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ANGPT2 — NFKB1

Text-mined interactions from Literome

Kranzhöfer et al., Biochem Biophys Res Commun 1999 (Arteriosclerosis...) : This study therefore examined the effect of angiotensin (ANG) II on NF-kappaB activation in monocytic cells, a major cellular component of human atheroma, by electrophoretic mobility shift assay ... ANG II , like TNFalpha, caused rapid activation of NF-kappaB in human mononuclear cells isolated from peripheral blood by Ficoll density gradient ... Moreover, ANG II stimulated NF-kappaB activation in human monocytes, but not in lymphocytes from the same preparation
Ruiz-Ortega et al., Circ Res 2000 : Ang II increased NF-kappaB DNA binding ( 5-fold, 10 ( - ) ( 9 ) mol/L at 1 hour ; electrophoretic mobility shift assay ), nuclear translocation of p50/p65 subunits, and cytosolic inhibitor kappaBalpha ( IkappaBalpha ) degradation
Brasier et al., Mol Cell Biochem 2000 : Although NF-kappaB is ubiquitously expressed, surprisingly the mechanism for Ang II-inducible NF-kappaB regulation differs between aortic smooth muscle cells ( VSMCs ) and hepatocytes
Ruiz-Ortega et al., Nephrol Dial Transplant 2001 : In VSMC from AT1 knockout mice, Ang II also activated NF-kappaB
Li et al., Chin Med J (Engl) 2002 : To examine the effect of angiotensin II (Ang II) on nuclear factor-kappa B (NF-kappaB) activation in human endothelial cell line ECV304 and the molecular mechanism by which Ang II activates NF-kappaB
Wolf et al., Kidney Int 2002 : In AT1 or AT2 receptor transfected cells, but not untransfected COS7 cells, 10-7 mol/L Ang II induced NF-kappaB DNA binding in vitro, as detected by electrophoretic shift assays and in vivo transactivation of a reporter gene construct ... Ang II-induced activation of NF-kappaB was associated with degradation of IkappaB-alpha in all studied cell lines
Dechend et al., Circulation 2003 (Pre-Eclampsia) : VSMC from p47phox-/- mice showed markedly reduced ROS generation and NF-kappaB activation in response to Ang II and AT1-AA
Wu et al., Mol Endocrinol 2004 : Ang II stimulation induced MCP-1 mRNA expression as well as an increase in nuclear factor-kappaB (NF-kappaB) binding to the corresponding cis DNA element of the MCP-1 promoter region and a decrease in the cytosolic inhibitory protein-kappaB ( IkappaB ) protein level via AT(1) receptor stimulation, whereas stimulation of the AT(2) receptor decreased Ang II-induced MCP-1 expression, NF-kappaB DNA binding, and IkappaB degradation, suggesting that activation of the AT(2) receptor attenuated AT(1) receptor mediated MCP-1 expression via a decrease in NF-kappaB DNA binding and an increase in IkappaB stability
Zhang et al., Arterioscler Thromb Vasc Biol 2005 (Vasculitis) : Downregulation of RSK by small interfering RNA ( SiRNA ) in VSMCs was found to suppress Ang II-induced activation of NF-kappaB and p65 phosphorylation
Esteban et al., Circ Res 2005 : Ang II activates NF-kappaB via AT1 and AT2 receptors, but AT1 or AT2 antagonists did not inhibit NF-kappaB activation caused by Ang IV
Chen et al., Cardiovasc Res 2006 : Ang II induced activation of NF-kappaB and AP-1 in untransfected VSMCs, however, Ang II induced significantly higher activities of these pro-inflammatory transcription factors in HSF-1 siRNA transfected cells
Chen et al., Arterioscler Thromb Vasc Biol 2006 : The critical role of NF-kappaB in Ang II-induced LOX-1 promoter activation was confirmed by mutagenesis assay, and further confirmed by blocking NF-kappaB activation with the NF-kappaB inhibitor caffeic acid phenethyl ester or NF-kappaB p65 siRNA
Tsuchiya et al., Am J Physiol Endocrinol Metab 2006 (Obesity) : ANG II induced translocation of NF-kappaB p65 subunit from cytoplasm to nucleus by immunocytochemical study
Li et al., Regul Pept 2007 (Liver Cirrhosis, Experimental) : The present study aims to investigate the signal transduction mechanism underlying effects of Ang II and Aldo on NF-kappaB and AP-1 pathway during hepatic fibrogenesis
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : Electrophoretic mobility shift assays and Western blotting revealed that Ang II , signaling via AT(1), produces a time dependent increase in NF-kappaB DNA binding and IkappaBalpha degradation ... These results also demonstrate that Ang II leads to MAPK phosphorylation and p38MAPK pathway induced NF-kappaB activation
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007 (Inflammation) : Much of this effect of Ang II results from activation of the proinflammatory NF-kappaB transcription factor in response to stimulation of the type 1 Ang II receptor, a G protein coupled receptor ... Here, we characterize a previously undescribed signaling pathway mediating Ang II-dependent activation of NF-kappaB , which is composed of three principal proteins, CARMA3, Bcl10, and MALT1
Takahashi et al., Atherosclerosis 2007 (Hypertrophy) : An electrophoretic mobility shift assay showed that Ang II increased the TRPC1 promoter 's NF-kappaB binding activity
Choudhary et al., Mol Endocrinol 2007 : Finally, we demonstrate that Ang II infusion in vivo rapidly induces phospho-Ser ( 536 ) RelA formation and activation of the NF-kappaB dependent IL-6 gene
Wei et al., Am J Physiol Endocrinol Metab 2008 (Insulin Resistance) : Moreover, ANG II treatment of L6 myotubes induced NF-kappaB activation and TNF-alpha production and decreased insulin stimulated Akt activation and GLUT-4 glucose transporter translocation to plasma membranes
Voegeli et al., Inflamm Res 2009 : The proinflammatory effects of Ang II on NF-kappaB in vascular smooth muscle cells may be through a non-canonical pathway and be dependent on p65 phosphorylation
Pan et al., Braz J Med Biol Res 2009 (Inflammation) : Ang II stimulation also promoted the activation of nuclear factor-kappa B (NF-kappaB)