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POLDIP2 — TNF
Text-mined interactions from Literome
Hashimoto et al., Biochem Biophys Res Commun 1999
:
We examined the regulatory role of a reduction/oxidation ( redox ) control protein, thioredoxin (TRX), in
tumor necrosis factor-alpha (TNF-alpha) induced
p38 MAP kinase activation and p38 MAP kinase mediated cytokine expression utilizing TRX transfected murine L929 cells ( TRX14 )
Leonard et al., Kidney Int 1999
(MAP Kinase Signaling System) :
Pretreatment with SB203580 ( 10 microM ) had no effect on basal or TNF-alpha stimulated phosphorylation of p38 MAPK but completely abolished
TNF-alpha stimulated
p38 MAPK activity
Hashimoto et al., Allergy 2000
:
Human pulmonary vascular endothelial cells were exposed to N-acetylcysteine (NAC) or buthionine sulfoximine ( BSO ), and then
TNF-alpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production were determined
Mochida et al., Kokubyo Gakkai Zasshi 2000
(MAP Kinase Signaling System) :
Apoptosis signal regulating kinase 1 ( ASK 1 ) is a mitogen activated protein ( MAP ) kinase kinase kinase ( MAPKKK ) that is
activated by
TNF and IL-1, and stimulates c-Jun N-terminal kinase ( JNK also known as SAPK ; stress activated protein kinase ) and
p38 activation
Hashimoto et al., Br J Pharmacol 2001
:
However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione ( GSH ) synthesis, on
TNF-alpha induced activation of p38 MAP kinase pathway and
p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined ... 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for
TNF-alpha induced activation of p38 MAP kinase pathway and
p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells, and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury
Hashimoto et al., Clin Exp Allergy 2001
:
However, a role of cellular redox regulated by intracellular glutathione ( GSH ) in
TNFalpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production by human BECs has not been determined ...
TNFalpha induced
p38 MAP kinase
activation and p38 MAP kinase mediated RANTES production by human BECs were then examined in order to clarify these issues
Kumar et al., J Cell Physiol 2001
(Bone Resorption) :
SB 203580, a selective inhibitor of p38 MAPK, inhibited IL-1 and
TNF induced
p38 MAPK activity and IL-6 production ( IC ( 50 ) s 0.3 -- 0.5 microM ) in osteoblasts and chondrocytes
Moore et al., J Appl Physiol 2001
:
Although IL-1 beta and
TNF-alpha each
increased nuclear factor-kappa B activation and induced extracellular regulated kinase and
p38 phosphorylation, combined administration of the cytokines did not enhance either nuclear factor-kappa B or mitogen activated protein kinase activation
Thurmond et al., Eur J Biochem 2001
:
These values closely match the IC ( 5 ) 0 values observed in a cell based TNF alpha release assay implying that
p38 plays a major role in
TNF alpha release
Pollock et al., Neuropharmacology 2002
(Calcium Signaling) :
Biochemical and immunocytochemical analysis showed that
TNF activated
p38 mitogen activated protein kinase ( p38MAPK ) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK
Nwariaku et al., Shock 2002
:
TNFalpha significantly increased permeability and
induced p38 and ERK MAPK activation compared with controls ( P < 0.05 )
Miakotina et al., Am J Physiol Lung Cell Mol Physiol 2002
:
TNF-alpha increased the phosphorylation of p38 MAPK within 15 min. Anisomycin, an activator of p38 MAPK, increased
p38 MAPK phosphorylation and decreased SP-A mRNA levels in a dose dependent manner
Masamune et al., Pancreas 2002
(Acute Disease...) :
IL-1 beta and
TNF-alpha activated extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase/stress activated protein kinase, and
p38 mitogen activated protein kinase
Jeohn et al., Neuroscience 2002
:
Gö6976
inhibits LPS induced microglial
TNFalpha release by suppressing
p38 MAP kinase activation
Nick et al., J Immunol 2002
(Inflammation) :
Release of
TNF-alpha , macrophage-inflammatory protein (MIP)-2 ( MIP-1beta ), and IL-8 by LPS stimulated neutrophils was also
reduced by poststimulation
p38 MAPK inhibition
Kasper et al., Blood 2004
:
Analyzing the individual contribution of PF-4 and its costimuli in the control of these functions at the signaling level, we demonstrate that
TNF induced activation of
p38 mitogen activated protein ( MAP ) kinase ( but not extracellular regulated kinase [ Erk ] kinases ) acts as general and essential costimulatory signal in PF-4 dependent neutrophil exocytosis
Hideshima et al., Cancer Res 2003
(Multiple Myeloma) :
Importantly, CT-32615 inhibited tumor necrosis factor-alpha triggered nuclear factor-kappaB activation but did not affect either
tumor necrosis factor-alpha induced
p38 mitogen activated protein kinase phosphorylation or interleukin 6-triggered signal transducers and activators of transcription 3 phosphorylation
Yoshizumi et al., Exp Cell Res 2004
:
Extracellular signal regulated kinase ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and
p38 were rapidly and significantly
activated by
TNF-alpha in HUVEC
Lüschen et al., Exp Cell Res 2004
:
Among other cellular responses,
tumor necrosis factor (TNF) induces different forms of cell death and the activation of the
p38 mitogen activated protein kinase ( MAPK )
Xu et al., J Biol Chem 2004
:
The
tumor necrosis factor receptor associated factor ( TRAF ) protein family members are critically
involved in activation of NF-kappaB, JNK, and
p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor ( TIR ) -containing receptors
Ait-Ali et al., Mol Endocrinol 2004
:
Stimulatory effects of
TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and
required activation of ERK 1/2 and
p38 , but not Janus kinase, MAPKs
Jijon et al., Cell Signal 2004
:
Interestingly, Ad5NIK, but not
TNF ,
induces RelA S536 and
p38 mitogen activated protein kinase ( MAPK ) phosphorylation in IKKgamma ( -/- ) cells
Kotani et al., Eur Respir J 2004
(Disease Models, Animal...) :
Physiological parameters,
tumour necrosis factor (TNF)-alpha , interleukin (IL)-8 and
activation of mitogen activated protein kinases ( extracellular signal regulated kinase ( ERK ) 1/2,
p38 and stress activated protein kinase ( SAPK ) / c-Jun N-terminal kinase (JNK) ) were measured
Garry et al., Mol Cell Neurosci 2005
(Disease Models, Animal...) :
Activation of
p38 and p42/44 MAP kinases in spinal cord ipsilateral to constriction injury was
reduced by antagonists of NMDA, VPAC2 and NK2 ( but not related ) receptors, the glial inhibitor propentofylline and inhibitors of
TNF-alpha
Jia et al., Zhonghua Wai Ke Za Zhi 2005
(Disease Models, Animal...) :
Similarly, the increased gene expression of proinflammatory cytokines
TNF-alpha and IL-1beta in gastric mucosa induced by WIR stress were significantly
diminished by
p38 MAPK inhibition
Beardmore et al., Mol Cell Biol 2005
(Arthritis...) :
As
p38 is
activated by
tumor necrosis factor , the p38beta-/- mice were crossed onto a TNFDeltaARE mouse line
Bhatnagar et al., Cell Microbiol 2006
(Mycobacterium avium-intracellulare Infection) :
Interestingly,
TNF-alpha secretion by macrophages infected with SmO or SmT 2151 was
dependent on
p38 , ERK1/2 and NF-kappaB while TNF-alpha secretion by Rg 2151 infected macrophages was dependent on NF-kappaB but not the MAPKs
Huang et al., Acta Med Okayama 2005
(Fibrosarcoma) :
TNFalpha induced
p38 and ERK activation, whereas oridonin triggered only ERK activation
Chen et al., Zhonghua Shao Shang Za Zhi 2005
(Burns) :
To investigate The modulating
role of
p38 mitogen activated protein kinase ( MAPK ) in the expression of
tumor necrosis factor-alpha in hepatic cells and its role in hepatic injury in severely burned rats
Granata et al., Eur J Immunol 2006
:
sPLA ( 2 )
induced the phosphorylation of the MAPK
p38 and ERK1/2, and inhibition of these kinases by SB203580 and PD98059, respectively, reduced
TNF-alpha and CXCL8 release
Oyama et al., J Periodontal Res 2007
:
Roxithromycin significantly inhibited
TNF-alpha induced c-Jun N-terminal kinase activation ( JNP ) and marginally
inhibited extracellular signal regulated kinase ( ERK ) 1/2 activation, but not
p38 mitogen activated protein kinase activation
Guilloton et al., Cell Signal 2007
(Leukemia, Myeloid, Acute) :
The effects of
TNFalpha and FasL on GrB expression were specifically
mediated by
p38MAPK ( Mitogen-activated-protein-kinase ) activation
Kesherwani et al., Cytokine 2007
:
Quantitative
role of p42/44 and
p38 in the production and regulation of cytokines
TNF-alpha , IL-1beta and IL-12 by murine peritoneal macrophages in vitro by concanavalin A ... In the present study the quantitative
role of p42/44 and
p38 in the production of
TNF-alpha , IL-1beta and IL-12 by murine peritoneal macrophages, in vitro, on treatment with Concanavalin A ( ConA ) has been investigated
Moussaieff et al., Mol Pharmacol 2007
:
The inhibitory effect seems specific ; IA did not interfere with
TNFalpha induced activation of c-Jun N-terminal kinase (JNK) and
p38 mitogen activated protein kinase
Tephly et al., Am J Respir Cell Mol Biol 2008
(Asbestosis) :
We have demonstrated that the
p38 mitogen activated protein ( MAP ) kinase
regulates TNF-alpha expression in monocytes exposed to asbestos
Deng et al., J Pharmacol Exp Ther 2008
:
We tested the hypothesis that
p38 mitogen activated protein kinase activation is
necessary for
TNF-alpha production, neutrophil activation, and subsequent liver injury
Busik et al., Diabetes 2008
(Diabetic Retinopathy...) :
Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production,
activation of nuclear factor-kappaB (NF-kappaB), extracellular signal related kinase ( ERK ),
p38 and Jun NH ( 2 ) -terminal kinase ( JNK ), tyrosine phosphorylation, interleukin (IL)-1beta, or
tumor necrosis factor-alpha (TNF-alpha) production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l )
Itatsu et al., Liver Int 2009
(Cholangiocarcinoma) :
As for the signalling pathway,
TNF-alpha stimulation
led to the phosphorylation of extracellular signal regulated kinase 1/2 ( Erk1/2 ) and
p38 mitogen activated protein kinase ( p38MAPK ) and translocation of nuclear factor kappaB (NF-kappaB) ( p65 ) into the nuclei
Zhang et al., Invest Ophthalmol Vis Sci 2009
(Diabetes Mellitus, Experimental...) :
Analysis of downstream signals showed that inhibition of NAD ( P ) H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent
TNF-alpha induced phosphorylation of
p38MAPK
Taniguchi et al., Mol Cell Endocrinol 2009
(Endometriosis) :
By transfection of TAK1 siRNA,
TNFalpha induced phosphorylation of IkappaBalpha, JNK1/2, and
p38MAPK , as well as IL-6 or IL-8 expression, were repressed
King et al., J Biol Chem 2009
:
This correlates with reduced
TNFalpha stimulated
p38 MAPK phosphorylation
Mao et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009
(Disease Models, Animal...) :
p38MAPK 's phosphorylation is important in pathogenesis of MODS, and phosphorylation of
p38MAPK can
enhance TNF-alpha mRNA transcription and secretion of
TNF-alpha from peripheral blood mononuclear cells, which is the mechanism of increased TNF-alpha in MODS
Faugaret et al., Mol Immunol 2010
(MAP Kinase Signaling System) :
Importantly, we showed that MPA more strongly inhibited
p38MAPK phosphorylation
induced by
TNFalpha than by LPS
Eda et al., Rheumatol Int 2011
(MAP Kinase Signaling System) :
IL-1ß and
TNF-a activated the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 MAPK,
p38 , and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts
Barbieri et al., Cardiovasc Res 2011
:
Inhibitors of NADPH oxidase and/or p47phox siRNA diminished ROS production and COX-2 expression as well as phosphorylation of
p38 mitogen activated protein kinase ( p38MAPK ) and Akt
mediated either by AS serum or by
TS/IL-1ß/TNF-a
Duffey et al., Head Neck 2011
(Carcinoma, Squamous Cell...) :
In this setting,
TNF increases
p-p38 phosphorylation and chemosensitivity while further enhancing IL-8 production
Wang et al., Invest Ophthalmol Vis Sci 2012
:
BBR inhibited the expression of IL-6, IL-8, and MCP-1 remarkably at both protein and mRNA levels and down-regulated the phosphorylation of
p38 , ERK1/2, and JNK upon
stimulation with
TNF-a
Huang et al., Pharm Biol 2012
(Atherosclerosis...) :
TNF-a induced JNK and
p38 activations, which were involved in ICAM-1 expression, were significantly inhibited with DTD serum treatment by 10-50 % on HUVEC
Kanaji et al., J Vasc Res 2013
(MAP Kinase Signaling System...) :
TNF-a specifically activated p38a but not other p38 isoforms and suppression of
p38a by an siRNA
resulted in further amplification of the TNF-a effect
Wu et al., Cell Res 2013
:
Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B, ERK, JNK, and
p38 in
response to
TNF and lipopolysaccharides (LPS), respectively
Schafer et al., J Immunol 1999
:
SB 203580, a selective inhibitor of p38, blocked
p38 and MAPKAPK-2 activation in the T cell clone but did not completely
inhibit TNF-alpha release