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NOXO1 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database RAC1 signaling pathway: RAC1/GTP complex (RAC1) → RAC1/GTP/NOX1/NOXA1/NOXO1 complex (RAC1-NOX1-NOXA1-NOXO1) (modification, collaborate)
  Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
  Evidence: assay, physical interaction
• NCI Pathway Database RAC1 signaling pathway: RAC1/GTP complex (RAC1) → NOX1/NOXA1/NOXO1 complex (NOX1-NOXA1-NOXO1) (modification, collaborate)
  Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
  Evidence: assay, physical interaction
• NCI Pathway Database RAC1 signaling pathway: RAC1/GTP/NOX1/NOXA1/NOXO1 complex (RAC1-NOX1-NOXA1-NOXO1) → NOX1/NOXA1/NOXO1 complex (NOX1-NOXA1-NOXO1) (modification, collaborate)
  Cheng et al., J Biol Chem 2006, Miyano et al., J Biol Chem 2006*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Geiszt et al., J Biol Chem 2003*, Takeya et al., J Biol Chem 2003

Text-mined interactions from Literome

Kawahara et al., Am J Physiol Cell Physiol 2005 : Thus the H. pylori LPS stimulated O2- production in gastric mucosal cells appears to require two distinct events : 1 ) transcriptional upregulation of Nox1 and NOXO1 and 2 ) activation of Rac1
Cheng et al., J Biol Chem 2006 : Rac1 ( G12V ) interaction with NOXA1 was enhanced by Nox1 and NOXO1 , suggesting cooperative binding