◀ Back to TNF

LEP — TNF

Text-mined interactions from Literome

Medina et al., Int J Obes Relat Metab Disord 1999 : TNF-alpha at concentrations of 0.024, 0.24, 2.4 and 24 ng/ml did not affect leptin secretion over 24 h. TNF-alpha at concentrations of 0.24 to 24 ng/ml significantly inhibited leptin secretion over 96 h by 19-60 % ... TNF-alpha at a concentration of 0.024 ng/ml did not affect leptin secretion, glucose uptake or lactate production
Gottschling-Zeller et al., Eur J Endocrinol 1999 : The aim of this study was to characterize the role of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 in depot-specific secretion of leptin from cultured human adipocytes ... We measured the leptin concentrations in the culture medium of omental and subcutaneous abdominal adipocytes taken from severely obese individuals and kept in suspension culture, and studied the effect of TNF-alpha and TGF-beta1 on leptin release
Uchida et al., Naunyn Schmiedebergs Arch Pharmacol 1999 : Protein kinase C mediates tumor necrosis factor-alpha induced inhibition of obese gene expression and leptin secretion in brown adipocytes ... To know whether TNF-alpha also affects late events in brown adipocyte maturation, we examined the effect of TNF-alpha on obese gene expression and leptin secretion in mouse brown adipocytes differentiated in culture ... TNF-alpha caused a concentration dependent decrease in leptin accumulation in culture medium and leptin mRNA amount in brown adipocytes which constitutively express the ob gene ... Time-course study showed that TNF-alpha significantly suppressed leptin secretion during incubation for 16, 24 and 48 h ... Since some effect of TNF-alpha is mediated by activation of protein kinase C ( PKC ), the role of PKC in TNF-alpha induced downregulation of ob gene expression and leptin secretion was studied ... The suppressive effect of TNF-alpha on both ob gene expression and leptin secretion was blocked by PKC inhibitors such as bisindolylmaleimide I ( BIM ) and 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine dihydrochloride ( H-7 )
Finck et al., Am J Physiol Regul Integr Comp Physiol 2000 : Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor ... The results using all four strategies show that the induction of leptin production by TNF-alpha requires activation of the p55 TNFR and that although activation of the p75 TNFR alone can not cause leptin production, its presence affects the capability of TNF-alpha to induce leptin production through the p55 TNFR
Faggioni et al., Proc Natl Acad Sci U S A 2000 (Drug-Induced Liver Injury) : These results demonstrate that leptin deficiency leads to reduced production of TNF-alpha and IL-18 associated with reduced T cell mediated hepatotoxicity
Zhang et al., Mol Cell Endocrinol 2000 : The acute and chronic effects of tumour necrosis factor-alpha (TNF-alpha) on leptin production by human preadipocytes, differentiated preadipocytes, and mature adipocytes have been examined by competitive RT-PCR of leptin mRNA and by western blotting ... TNF-alpha blocked leptin synthesis during differentiation ... In contrast, TNF-alpha ( 4-8-h treatment ) resulted in a 4-fold increase in leptin release ... We conclude that TNF-alpha stimulates the release of preformed leptin from human mature adipocytes and existing differentiated preadipocytes, which may contribute to obesity/infection linked hyperleptinemia, and that TNF-alpha inhibits leptin synthesis via inhibition of preadipocyte differentiation and induction of adipocyte dedifferentiation
Finck et al., Microsc Res Tech 2000 (Cachexia...) : Tumor necrosis factor-alpha regulates secretion of the adipocyte derived cytokine, leptin
Cakir et al., Horm Res 1999 (Body Weight...) : Pretreatment serum leptin ( 4.5 +/- 0.9 vs. 2.1 +/- 0.2 ng/ml, respectively ; p < 0.05 ) and plasma TNFalpha ( 27.9 +/- 3.4 vs. 23.9 +/- 3.0 pg/ml, respectively ; p < 0.05 ) levels of the patients were significantly higher than those of the controls. After treatment, serum leptin levels increased to 6.7 +/- 2.2 ng/ml, but this rise was not statistically significant ( p > 0.05 )
Kato et al., Clin Nephrol 2001 (Kidney Diseases) : The expression of leptin , an adipocyte derived protein, is regulated by tumor necrosis factor-alpha (TNF-alpha)
Mastronardi et al., Proc Natl Acad Sci U S A 2002 (Body Weight) : Leptin increased tumor necrosis factor (TNF)-alpha release at a 100-fold lower dose than required for NO release in vitro and in vivo, suggesting that it also may participate in leptin induced NO release ... However, because many molecules of leptin were required to release a molecule of TNF-alpha in vivo and in vitro, we believe that leptin induced TNF-alpha release is an associated phenomenon not involved in NO production
Chu et al., Clin Biochem 2002 (Obesity) : However, TNF-R1 plays a more significant role in leptin expression among girls only
Medina et al., Metabolism 2002 (Diabetes Mellitus, Experimental...) : Since TNF-alpha also induces hyperinsulinemia, and because insulin is a potent stimulator of leptin production, we hypothesized that elevated plasma insulin mediates TNF-alpha induced increases of circulating leptin ... In nondiabetic rats, TNF-alpha increased plasma insulin ( P =.016 ) and prevented the fasting induced decrease of circulating leptin ( P =.004 ) over the initial 12 hours compared with vehicle ... These results suggest that TNF-alpha induced hyperinsulinemia likely mediates the stimulatory effect of TNF-alpha on circulating leptin in vivo
Lambert et al., J Gerontol A Biol Sci Med Sci 2003 (Weight Gain) : IL-6 was reduced by MA except when RT was undertaken ; TNF alpha was reduced over time regardless of group ; leptin was higher in individuals not on T than those on T ; and the change in plasma leptin was correlated with the change in fat mass
Gaetke et al., J Am Coll Nutr 2003 (Autoimmune Diseases...) : The objective of this study was to examine whether increased tumor necrosis factor-alpha (TNF-alpha) , a pro-inflammatory cytokine, contributes to the abnormally elevated leptin in IL-2 ( -/- ) mice
Frisullo et al., J Clin Immunol 2004 (Multiple Sclerosis, Relapsing-Remitting) : Our data showed that leptin induced tumor necrosis factor-alpha , interleukin-6, and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls
Härle et al., Ann Rheum Dis 2004 (Arthritis, Rheumatoid...) : Leptin is stimulated by TNF and is associated with hypoandrogenicity in non-inflammatory conditions
Sato et al., Adv Exp Med Biol 2003 (Anorexia...) : Tumor Necrosis Factor (TNF) and/or interleukin-1 (IL-1) stimulate leptin release, but not insulin
Erkasap et al., J Physiol Biochem 2004 (Disease Models, Animal...) : The purpose of the study was to evaluate the effects of leptin on renal tissue TNF-alpha , malondialdehyde ( MDA ), protein carbonyls ( PCs ) and total sulfydryl group ( SH ) levels, and plasma nitrite levels after renal I/R injury in rats
Franchimont et al., J Clin Endocrinol Metab 2005 (Crohn Disease...) : The regulation of leptin by TNFalpha is poorly understood in CD ... Pharmacological neutralization of TNFalpha with infliximab offers a unique opportunity to study TNFalpha mediated regulation of leptin in CD patients
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not leptin
Shen et al., Life Sci 2005 : Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS stimulated Kupffer cells ... Here we showed the effects of leptin on the production of TNF-alpha ( tumor necrosis factor-alpha ) by Kupffer cells (KCs) with signal transduction ... Leptin enhanced TNF-alpha production accompanied by a dose dependent increase of MAPK activity in lipopolysaccharide (LPS) stimulated KCs
Sun et al., Zhonghua Nei Ke Za Zhi 2005 (Diabetes Mellitus, Type 2...) : Serum levels of TNFalpha and leptin in obese subjects are closely related with insulin resistance, indicating that high level of TNFalpha may promote release of leptin for the modulation of adipocyte
Simons et al., Cytokine 2005 : However, TNF-alpha , IL-1beta, and TGF-beta1 stimulated leptin production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml, 100.8+/-18.2 ng/ml, and 5.4+/-0.4 ng/ml, respectively, compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 )
Trujillo et al., J Clin Endocrinol Metab 2006 (Obesity) : TNF increases plasma leptin in humans in vivo, but previous studies showed it decreases leptin in vitro ... The objective of this study was to determine the effect of TNF on leptin release from human adipose tissue ( AT ) from healthy subjects undergoing elective surgery or needle aspirations of AT at a university hospital ... In contrast, when added in the presence of dex, TNF increased secreted leptin and leptin mRNA abundance in AT from nonobese and obese subjects ... Synergistic effects of increased local or systemic TNF in combination with glucocorticoids may contribute to increased leptin expression in response to stress, including infection and obesity
Zhao et al., Cell Immunol 2005 (MAP Kinase Signaling System) : Globular adiponectin decreases leptin induced tumor necrosis factor-alpha expression by murine macrophages : involvement of cAMP-PKA and MAPK pathways ... Leptin stimulated TNF-alpha production at mRNA as well as protein levels in a dose- and time dependent manner ... gAd inhibited leptin induced TNF-alpha production through suppressing phosphorylation of ERK1/2 and p38 pathways
Simons et al., J Endocrinol 2007 (Insulin Resistance) : Despite this reduction of lipid-laden adipocytes, TNF-alpha , IL-6/sIL-6R, and IL-1beta stimulated leptin release
Balasubramaniyan et al., Cytokine 2007 : The aim of our present work was to study the effect of exogenous leptin and/or ethanol on the secretion of TNF-alpha , IL-6 and TGF-beta1 both in vivo and in vitro
Ahmed et al., J Vet Med Sci 2007 : Leptin treatment augmented the monocyte/macrophages mRNA expression of only TNF-alpha and IL-12p40 to comparable levels of cells treated with lipopolysaccharide (LPS)
Rafail et al., Thromb Res 2008 (Inflammation...) : Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2 dependent mechanisms and TNFalpha involvement
Sonoda et al., Endocrinology 2008 : Adiponectin and leptin , and adipocyte-specific genes of adiponectin, leptin, and PPAR-gamma were detected in culture assembly, whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent TNF-alpha ( 2 nm ) increased and decreased, respectively, all of their displays
Park et al., Joint Bone Spine 2009 (Spondylitis, Ankylosing) : Stimulation of PBMCs by exogenous leptin significantly increased the production of IL-6 and TNF-alpha in PBMCs from patients with AS in a dose dependent fashion and these increases were much exacerbated compared to controls
Orlova et al., Bull Exp Biol Med 2009 : Leptin increased the expression of HLA-DR on T lymphocytes, stimulated the production of TNF-alpha and IL-6, and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes
Ryan et al., Pflugers Arch 2010 : The PPARgamma agonist rosiglitazone stimulated both adiponectin and leptin expression and inhibited the expression of IL-6, MCP-1 and TNFalpha ; MCP-1 secretion was reduced
Kim et al., Journal of periodontal & implant science 2010 : The purpose of this study was to investigate the effect of leptin on Prevotella ( P. ) intermedia lipopolysaccharide (LPS) induced tumor necrosis factor (TNF)-alpha production in differentiated THP-1 cells, a human monocytic cell line ... Effect of leptin on P. intermedia LPS induced TNF-alpha production was not mediated by the leptin receptor
Herrejón et al., Med Clin (Barc) 2011 (Body Weight...) : The IL-6 and TNF alpha levels were not modified in the MA group, but leptin did increase ( p < 0.043 )
Kopec-Medrek et al., Rheumatol Int 2012 (Arthritis, Rheumatoid) : TNF-a was also found to enhance synthesis of leptin ... It is possible that TNF-a induced leptin secretion contributes to body mass reduction in patients with RA
Jaedicke et al., J Leukoc Biol 2013 : Additionally, leptin potentiated Escherichia coli and Porphyromonas gingivalis LPS induced TNF-a secretion in THP-1 monocytes
Mantzoros et al., J Clin Endocrinol Metab 1997 (Diabetes Mellitus, Type 2) : The expression of leptin , an adipocyte derived protein whose circulating levels reflect energy stores, can be induced by tumor necrosis factor (TNF)alpha in rodents, but an association between the TNF alpha system and leptin levels has not been reported in humans
Granowitz et al., Biochem Biophys Res Commun 1997 (Inflammation) : When considered in the context of animal studies showing that interleukin-1 and tumor necrosis factor-alpha induce leptin and ob mRNA, these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta
Yamaguchi et al., Biochem Biophys Res Commun 1998 : Moreover, human TNF-alpha ( h-TNF-alpha ) also inhibited human-leptin ( h-leptin ) secretion by cultured human adipocytes collected from the subcutaneous fat of pregnant women ... These results suggest that TNF-alpha , which is secreted by adipocytes, inhibits m-leptin secretion through mTNF-RI and suggest the presence of an autocrine or paracrine regulation of leptin secretion in human and mouse adipose tissue in vivo
Finck et al., Endocrinology 1998 : In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide ... To examine the role of tumor necrosis factor-alpha (TNF alpha) in mediating leptin secretion during an immunological challenge, we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice, endotoxin-insensitive C3H/HeJ ( HeJ ) mice, and primary adipocytes cultured from both ... To determine whether TNF alpha induces leptin secretion by acting directly on fat cells, primary adipocytes from OuJ and HeJ mice were cultured in the presence of TNF alpha or LPS
Takahashi et al., J Exp Med 1999 (Inflammation) : Since TNF also induces leptin , a hormone secreted by adipocytes that modulates food intake and metabolism, we questioned the role of leptin in TNF induced pathology