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LIF — POU5F1
Text-mined interactions from Literome
Davey et al., Stem Cells 2006
:
ESC colonies demonstrated radial organization of phosphorylated signal transducer and activator of transcription 3, Nanog, and
Oct4 ( among others ) in the
presence and absence of exogenous
leukemia inhibitory factor (LIF)
Debeb et al., PloS one 2009
:
Like ES cells, the XEN-P cells express
Oct4 and SSEA1 at high levels and their growth is
stimulated by
leukemia inhibitory factor , but instead of the epiblast determinant Nanog, they express the ExEn determinants Gata6 and Gata4
Singh et al., Biochem Biophys Res Commun 2009
:
In the
presence of
LIF , mES cells adherent to the FIII9'10-dimer showed transient upregulation of
Oct-4 , the mesodermal transcription factor, Brachyury, and the ectodermal marker, Nestin
Hall et al., Cell stem cell 2009
:
Oct4 primarily
induces Klf2 while
LIF/Stat3 selectively enhances Klf4 expression
Vizlin-Hodzic et al., Cellular reprogramming 2011
:
Depletion of SAF-A decreases
Oct4 expression even in the
presence of
LIF , and results in an increase of the mesodermal marker Brachyury