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AKT3 — CD40LG
Text-mined interactions from Literome
Arron et al., J Biol Chem 2001
:
A positive regulatory role for Cbl family proteins in tumor necrosis factor related activation induced cytokine ( trance ) and
CD40L mediated
Akt activation ... TRANCE and CD40L mediated Akt activation is defective in Cbl-b -/- dendritic cells, and
CD40L mediated
Akt activation is defective in c-Cbl -/- B cells
Tai et al., Cancer Res 2005
(Multiple Myeloma) :
Immunoblotting analysis specifically showed that
PI3-K/AKT , nuclear factor-kappaB (NF-kappaB), and extracellular signal regulated kinase activation
induced by
CD40L ( 5 mug/mL ) was inhibited by CHIR-12.12 ( 5 mug/mL )
Chakrabarti et al., Arterioscler Thromb Vasc Biol 2005
(Atherosclerosis...) :
Soluble
CD40L enhances platelet activation, aggregation, and platelet-leukocyte conjugation, as well as
increases stimulation induced platelet release of RONS through activation of
Akt and p38 MAP kinase signaling pathways
Georgakis et al., Br J Haematol 2006
(Hodgkin Disease) :
Akt phosphorylation was further
induced by CD30 ligand (CD30L),
CD40L and receptor activator of nuclear factor kappa B ( RANK ) ligand
Chakrabarti et al., J Biol Chem 2007
(Inflammation) :
These data support a mechanism whereby redox-sensitive
CD40-CD40L interactions
induce activation of
Akt and p38 MAPK, leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1