Gene interactions and pathways from curated databases and text-mining

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EPHB2 — TRH

Text-mined interactions from Literome

Le Péchon-Vallée et al., Neuroendocrinology 2000 (MAP Kinase Signaling System) : ERK activation by VIP or PACAP38 and TRH were additive and both sensitive to the MEK inhibitors PD98059 and U0126
Banihashemi et al., Mol Endocrinol 2002 : D2S stimulation also decreased TRH induced MAPK/ERK kinase phosphorylation
Van-Ham et al., J Neurochem 2007 : Activation of rat or human dopamine-D ( 2 ) S, muscarinic or somatostatin receptors inhibited thyrotropin releasing hormone induced ERK1/2 phosphorylation, while the D ( 2 ) L receptor failed to inhibit this response ... In transfected GH4 cells, the D ( 2 ) L-SS mutant inhibited thyrotropin releasing hormone induced ERK1/2 phosphorylation almost as strongly as the D ( 2 ) S receptor
Nafisi et al., J Biol Chem 2008 : In these clones, D2S mediated inhibition of TRH induced phospho-ERK1/2 was reversed by 70-80 % compared with parental GH4ZR7 cells
Mijiddorj et al., Endocr J 2012 : In addition, TRH induced ERK ( Extracelluar signal regulated kinase ) activation was enhanced in the presence of NKB