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TLR3 — TP53

Text-mined interactions from Literome

Taura et al., Mol Cell Biol 2008 : p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines ... Here we show that the tumor suppressor p53 positively regulates the transcription of TLR3 , a receptor for viral double stranded RNA and poly ( I-C ), by binding to the p53 site in the TLR3 promoter
Taura et al., Cancer Sci 2010 (Adenocarcinoma...) : Recently, we reported that tumor suppressor p53 increases the expression of TLR3 in several tumor cell lines
Pang et al., Cell cycle (Georgetown, Tex.) 2011 : TLR3-IRF1 or ATM dependent signaling to p53 is defective in p21-null cells and complementation of the p21 gene in p21-null cancer cells restores the p53 transcriptional response
Shatz et al., Cancer Res 2012 (Adenocarcinoma...) : The effect of DNA stressors on TLR expression was mainly mediated by p53 , and several p53 cancer associated mutants dramatically altered the pattern of TLR gene expression ... In all cell lines tested, TLR3 induction was p53 dependent , whereas induction of TLR9, the most stress-responsive family member, was less dependent on status of p53 ... In all cell lines tested, TLR3 induction was p53 dependent , whereas induction of TLR9, the most stress-responsive family member, was less dependent on status of p53
Menendez et al., Curr Opin Oncol 2013 (Neoplasms) : Activation of p53 by common antitumor agents results in p53 dependent regulation of expression of most TLR genes in human primary and cancer cell lines, resulting in modulation of TLR downstream responses to cognate ligands ... In addition several tumor associated p53 mutants can also affect TLR gene expression