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LPA — TP53

Text-mined interactions from Literome

Murph et al., Mol Cancer Res 2007 (Carcinoma...) : Here, we provide the first evidence that LPA reduces the cellular abundance of the tumor suppressor p53 in A549 lung carcinoma cells, which express endogenous LPA receptors ... Inhibition of phosphatidylinositol 3-kinase protected cells from the LPA induced reduction of p53 , which implicates this signaling pathway in the mechanism of LPA induced loss of p53
Rhim et al., Rejuvenation Res 2008 : Our data demonstrated that both LPA and ACI inhibit the catalytic activity of AMPKalpha and p53 by differentially regulating phosphorylation of AMPKalpha, causing increased senescent cell proliferation
Kanehira et al., PloS one 2012 : Expressions of p16(Ink4a), Rb, p53 , and p21 ( Cip1 ), which have been associated with cellular senescence, were all reduced in human MSCs by the pharmacological inhibition of LPA signaling
Iwabayashi et al., Biochem Biophys Res Commun 2012 (Atherosclerosis...) : On the other hand, HGF significantly attenuated EPC dysfunction, senescence, ROS production, and p53 and p21 expression induced by Lp(a)
Lee et al., J Biol Chem 2013 (Colonic Neoplasms) : A decrease in p53 expression was dependent on induction of p53-specific E3 ubiquitin ligase Mdm2 by LPA