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CDC25C — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
TP53
—
CDC25C
(in vitro)
Rief et al., Int J Oncol 2000*, Chen et al., FEBS Lett 2006*
-
IRef Hprd Interaction:
TP53
—
CDC25C
(in vivo)
Rief et al., Int J Oncol 2000*, Chen et al., FEBS Lett 2006*
-
IRef Ophid Interaction:
CDC25C
—
TP53
(aggregation, confirmational text mining)
Rief et al., Int J Oncol 2000*
-
IRef Ophid Interaction:
CDC25C
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Aguda et al., Proc Natl Acad Sci U S A 1999
:
The detailed model could be used to explain various experiments relevant to G2DDC reported recently, including the nuclear export of 14-3-3 bound Cdc25, the down-regulation of cyclin B1 expression by p53, the
effect of Chk1 and
p53 on
Cdc25 levels, and Wee1 degradation
St Clair et al., Mol Cell 2004
:
DNA damage induced downregulation of
Cdc25C is
mediated by
p53 via two independent mechanisms : one involves direct binding to the cdc25C promoter ...
Repression of
Cdc25C by
p53 represents an additional mechanism for p53 dependent cell cycle arrest in response to DNA damage
St Clair et al., Cell cycle (Georgetown, Tex.) 2006
:
The
dual specificity phosphatase Cdc25C is a direct
target for transcriptional repression by the
tumor suppressor p53
Tang et al., Cancer prevention research (Philadelphia, Pa.) 2008
(Carcinoma, Papillary...) :
Suppression of
p53 expression by small interfering RNA in RT4 cells
restored Cdc25C expression and down-regulated p21/WAF1 expression, which allowed Cdc25C and CDK1 activation, which then led to a G ( 2 ) -M arrest and an enhanced growth-inhibitory effect by flavokawain A. Consistently, flavokawain A also caused a pronounced CDK1 activation and G ( 2 ) -M arrest in p53 knockout but not in p53 wild-type HCT116 cells
Hseu et al., Evidence-based complementary and alternative medicine : eCAM 2011
:
This cell cycle blockade was associated with reductions in cyclin A and B1, Cdc2, and
Cdc25C , and
increased p21/WAF1, Wee1,
p53 and phospho-p53 ( p-p53 ) in a dose- and time dependent manner