Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — CCL5

Text-mined interactions from Literome

Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : The inhibitory effect of CCL5 on Ang II-induced 12-LO mRNA expression was mediated through the AT(2) receptor
Yun et al., Hypertens Res 2011 : Moreover, Ang II inhibited CCL5 expression in SHR VSMCs, but not in WKY VSMCs. Inhibition of CCL5 by Ang II was mediated by both Ang II subtype 1 receptor ( AT(1)R ) and subtype 2 receptor ( AT(2)R ) activation in SHR VSMCs ... This result suggests that upregulation of 12-LO by Ang II leads to the downregulation of CCL5 expression in SHR VSMCs