◀ Back to IFNG

IFNG — PTX3

Text-mined interactions from Literome

Fujimoto et al., Intern Med 1999 (Paraparesis, Tropical Spastic) : PTX treatment also induced a decrease in IFN-gamma levels in the sera of 6 HAM patients, but this was not correlated with clinical improvement
Luchetti et al., Clin Exp Immunol 2000 (Arthritis, Rheumatoid...) : In contrast, interferon-gamma and transforming growth factor-beta inhibited PTX3 constitutive expression in RA synoviocytes
Goodman et al., J Leukoc Biol 2000 : Finally, interferon-gamma ( IFN-gamma ; but not IFN-alpha/beta ) inhibited LPS induced TSG-14 expression in macrophages and not in 3T3 fibroblasts ... Inhibition of LPS induced TSG-14 mRNA expression by IFN-gamma in macrophages was also observed in the presence of cycloheximide and in cells from STAT1 null mice, suggesting that IFN-gamma inhibits TSG-14 expression through an unconventional mechanism
Marcinkiewicz et al., Immunopharmacology 2000 : PTX also affects the production of other cytokines such as IL-1, IL-6, IL-10, IL-12, and IFN-gamma
Samardzic et al., Clin Exp Immunol 2001 : The effect of phosphodiesterase inhibiting anti-inflammatory drug pentoxifylline ( PTX ) on LPS induced IL-18 synthesis and IL-18 mediated IFN-gamma-induction were investigated ... Synergistic induction of IFN-gamma by combined IL-12/IL-18 treatment was also inhibited by PTX in vitro and in vivo
Laurat et al., Circulation 2001 (Arteriosclerosis...) : In vitro addition of PTX to cultured spleen cells did not modify the production of IFN-gamma but increased the production of IL-10 by T cells, indicating that PTX does not suppress IFN-gamma production but rather blocks Th1 polarization while promoting Th2 polarization
Takehana et al., Circ J 2002 (Autoimmune Diseases...) : PTX in vitro could suppress T cell proliferation and inhibit TNF-alpha and interferon-gamma production
Luchetti et al., Clin Exp Rheumatol 2004 (Scleroderma, Systemic) : In contrast, IFN-gamma and TGF-beta inhibited the constitutive but not the stimulated expression of PTX3 in SSc fibroblasts
Zhang et al., J Immunother 2007 : PTX significantly reduced the production of TNF-alpha and IFN-gamma in mature DCs ( mDCs )
Spach et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental...) : However, only RANTES, IL-6, and IFN-gamma increased significantly with both genetic compensation and PTX treatment
Hofstetter et al., Neurosci Lett 2010 (Disease Models, Animal...) : We therefore investigated potential differences in the temporal and spatial kinetics of the PTX induced neuroantigen-specific IFN-gamma- and IL-17 producing T cell effector populations ... The highest frequencies of PTX induced IFN-gamma- and IL-17 producing PLPp-specific cells coincided in the inflamed CNS during acute EAE
Rieneck et al., Immunol Lett 1993 : The expression of tumour necrosis factor (TNF)alpha, TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX
Bruynzeel et al., J Invest Dermatol 1995 : In keratinocyte monolayers the interferon-gamma or tumor necrosis factor-alpha induced intercellular adhesion molecule-1 expression could not be inhibited by PTX
Benbernou et al., J Cardiovasc Pharmacol 1995 : Our findings showed that PTX at the appropriate concentrations could induce selective suppression of IL-2 and IFN-gamma , whereas at high concentrations this drug could act as a suppressive agent of both Th1- and Th2 derived cytokines
Navarro et al., AIDS 1996 : Moreover, PTX reduced TNF-alpha, IFN-gamma and IL-10 production and NF-kappa B activation
Funk et al., Int J Immunopharmacol 1995 : Similarly, PTX and CsA synergistically inhibited the release of IL-2, IFN-gamma and, to a lesser degree, TNF-alpha
Tsujino et al., J Neuroimmunol 1997 (Paraparesis, Tropical Spastic) : To clarify if pentoxifylline ( PTX ) may have therapeutic potential for human T-cell lymphotropic virus type I ( HTLV-I ) -associated myelopathy ( HAM ), we investigated the in vitro effect of PTX on spontaneous proliferation of peripheral blood lymphocytes ( SPP ), as well as on the expression of adhesion molecules, such as lymphocyte function antigen-1 ( LFA-1 ) and very late activation antigen-4 (VLA-4), and the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and granulocyte-monocyte colony stimulating factor ( GM-CSF ), in cultured PBMC from 10 HAM patients, compared with control subjects
Polentarutti et al., Eur J Immunol 1998 : Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes ... In the present report, we show that interferon-gamma (IFN-gamma) inhibits the expression of the PTX3 gene induced by exposure to IL-1, TNF or lipopolysaccharide in human monocytes
Weber et al., Ann Neurol 1998 (Multiple Sclerosis) : In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline ( PTX ) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin ( LT ), and interferon-gamma (IFN-gamma)