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CDKN1A — RAD50

Text-mined interactions from Literome

Shin et al., Cell Growth Differ 2001 (Adenocarcinoma...) : After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21 ( WAF1/CIP1 ) but not p53 was increased ... Our results indicate that overexpressed hRAD50 has an antiproliferation activity in vitro and in vivo in a p21 dependent manner
Liu et al., Anticancer Res 2011 (Breast Neoplasms) : The p53 pathway was involved in the synergism of RAD001 and carboplatin on breast cancer cell proliferation and apoptosis, since the synergistic effect was demonstrated in all tested breast cancer cell lines with wild-type p53 and the use of p53 inhibitor partially antagonized the effect of RAD001 and carboplatin on p53 and p21 expression, as well as their inhibitory effect on cell proliferation