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EPHB2 — SOAT1

Text-mined interactions from Literome

Dijkers et al., Oncogene 1999 : Tyrosine 577 and 612 were found to be critical for the activation of PKB and ERK1 , but not activation of STAT transcription factors
Cacalano et al., Nat Cell Biol 2001 : A tyrosine mutant of SOCS-3 still blocks STAT phosphorylation, but also strongly inhibits IL-2 dependent activation of ERK and cell proliferation
Kamimura et al., Rev Physiol Biochem Pharmacol 2003 (Acute-Phase Reaction...) : Intriguingly, recent in vivo studies indicated that the SHP-2 binding site- and YXXQ mediated pathways through gp130 are not mutually exclusive but affect each other : a mutation at the SHP-2 binding site prolongs STAT3 activation, and a loss of STAT activation by gp130 truncation leads to sustained SHP-2/ERK MAPK phosphorylation
Krasilnikov et al., Oncogene 2003 (Melanoma) : ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells : implications towards sensitization to apoptosis
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Luo et al., Eur J Neurosci 2007 (Optic Nerve Injuries) : In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and JAK/STAT , but not MEK/ERK, activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong PI3K/akt, JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury
Sengupta et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate an ERK mediated mechanism for inhibiting IL-6 induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway
Jain et al., Oncogene 1998 : We investigated the role of ERK on the regulation of STAT activity