◀ Back to EPHB2

EFNA5 — EPHB2

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHB forward signaling: Ephrin A5/EPHB2 complex (EFNA5-EPHB2) → EPHB2 (EPHB2) (modification, collaborate) Himanen et al., Nat Neurosci 2004*
  Evidence: assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin A5/EPHB2 complex (EFNA5-EPHB2) → Ephrin A5 (EFNA5) (modification, collaborate) Himanen et al., Nat Neurosci 2004*
  Evidence: assay, physical interaction
• NCI Pathway Database EPHB forward signaling: EPHB2 (EPHB2) → Ephrin A5 (EFNA5) (modification, collaborate) Himanen et al., Nat Neurosci 2004*
  Evidence: assay, physical interaction
• Reactome Reaction: EFNA5 → EPHB2 (reaction) Marignani et al., J Cell Biol 2001, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: EPHB2 — EFNA5 (in vitro) Himanen et al., Nat Neurosci 2004*

Text-mined interactions from Literome

Himanen et al., Nat Neurosci 2004 (Infection...) : Repelling class discrimination : ephrin-A5 binds to and activates EphB2 receptor signaling
Yue et al., Dev Neurobiol 2008 : These analyses showed that ephrin-A5 inhibits Erk activity but activates c-Jun N-terminal kinase
Meier et al., PloS one 2011 : Ephrin-A5 suppressed BDNF induced ERK activity and might sequester P-ERK in the cytoplasm