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BCL2 — IL7
Text-mined interactions from Literome
Hofmeister et al., Cytokine Growth Factor Rev 1999
:
This protection is partly mediated by
IL-7 induction of
Bcl-2 , however other IL-7 induced events are probably also involved in the trophic response
Graninger et al., Cell Death Differ 2000
(Lupus Erythematosus, Systemic) :
IL-2, IL-4,
IL-7 and IL-15
led to a significant increase in
Bcl-2 and a reduction in cell death rates, which was even more pronounced in SLE
Ducrey-Rundquist et al., J Virol 2002
:
Furthermore, the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin blocked
IL-7 induced cell survival and
Bcl-2 synthesis but had no effect on the acquisition of HIV susceptibility, suggesting that IL-7 induced HIV type 1 permissiveness is not mediated by the PI-3 K pathway and that, perhaps, the Jak/STAT5 pathway, the other known mediator of IL-7 triggered signaling in T cells, governs this process
Barata et al., J Exp Med 2004
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K activation was mandatory for
IL-7 mediated
Bcl-2 up-regulation, p27kip1 down-regulation, Rb hyperphosphorylation, and consequent viability and cell cycle progression of T-ALL cells
Yang et al., J Immunol 2008
:
However,
IL-7 induced expressions of
Bcl2 family members ( Bcl2, Bcl-x ( L ), Bax, and Bad ) were similar between naive and memory cells
Faller et al., Int Immunol 2009
(HIV Infections) :
Interestingly, while Tat acts synergistically with IL-7 to reduce CD127 expression, it antagonizes IL-7 induced cell proliferation and Ki-67 expression and has no effect on
IL-7 mediated signal transducer and activator of transcription 5 ( STAT5 ) phosphorylation or expression of the anti-apoptotic gene
Bcl-2
Kasten et al., Infect Immun 2010
(Disease Models, Animal...) :
Next,
IL-7 increased
Bcl-2 expression in T cells isolated from septic mice as early as 3 h following treatment
Vranjkovic et al., J Leukoc Biol 2011
(HIV Infections) :
In contrast,
IL-7 induced
Bcl-2 expression was not impaired in CD8 ( + ) CD127 ( + ) T cells from HIV ( + ) individuals
Lee et al., Oncogene 1996
(Lymphoma, T-Cell) :
The expression of
Bcl-2 protein was down-regulated when CS-21 cells were cultured alone, but the addition of
IL-7 recovered the expression of Bcl-2
Banerjee et al., J Immunol 1998
(Cell Transformation, Viral) :
IL-7 also
delayed the decreases in the levels of c-Myc, Bcl-2, and
Bcl-xL that occur upon loss of v-Abl kinase activity
Soares et al., J Immunol 1998
:
IL-7 prevented the decrease in Bcl-2 and
Bcl-xL and induced cell cycling in up to 20 % of cord T cells after 8 days, resulting in a threefold increase in cord T cell numbers