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IL3 — RAC1

Text-mined interactions from Literome

Arai et al., Oncogene 2002 : Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway ... Here we report that Epo or IL-3 rapidly and transiently activates Rac , a Rho family GTPase, in hematopoietic cell lines, 32D/EpoR-Wt and UT-7 ... Together, these results indicate that Rac is activated by Epo or IL-3 at downstream of the Ras/PI3K pathway in parallel with Akt and plays a role in activation of the Erk/Elk-1 signaling pathway in hematopoietic cells
Grill et al., Blood 2002 (MAP Kinase Signaling System) : Interleukin-3 (IL-3) induced activation of endogenous Rac-1 , Rac-2, and Cdc42 ... The activation of Rac-1 induced by cross linking the BCR or by IL-3 stimulation was blocked only partially by Ly294002, with about 25 % to 30 % of Rac-1 activation still occurring in the absence of detectable increases in phosphatidyl-inositol-3 kinase (PI-3K) activity