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GRK7 — GRM1

Text-mined interactions from Literome

Dhami et al., J Biol Chem 2004 : Here we show that GRK2 mutants impaired in Galphaq/11 binding ( R106A, D110A, and M114A ), bind effectively to mGluR1a, but do not mediate mGluR1a adaptation
Mundell et al., Mol Pharmacol 2004 : Together, these results indicate that PKA activation inhibits the agonist induced internalization and desensitization of mGluR1a and mGluR1b, probably by reducing their interaction with GRK2 and nonvisual arrestins
Mundell et al., Biochemistry 2004 : In co-immunoprecipitation studies, both glutamate and carbachol increased the association of GRK2 with mGluR1a ... Co-addition of the protein kinase C ( PKC ) inhibitor GF109203X and the Ca ( 2+ ) calmodulin dependent kinase II ( CaMKII ) inhibitor KN-93 blocked the ability of glutamate and carbachol to increase the association of GRK2 with mGluR1a ... Glutamate also increased the association of GRK2 with mGluR1b , whereas carbachol did not ... Furthermore, LY367385 blocked the ability of carbachol to increase the association of GRK2 with mGluR1a
Dhami et al., J Biol Chem 2005 : Mutation of either Lys ( 691 ) or Lys ( 692 ) prevented GRK2 mediated attenuation of mGluR1b signaling, whereas the mutation of only Lys ( 692 ) prevented GRK2 mediated inhibition of mGluR1a signaling
Dhami et al., Pharmacol Ther 2006 : However, GRK2 mediated mGluR1 desensitization appears to be both phosphorylation- and beta-arrestin independent