Gene interactions and pathways from curated databases and text-mining

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CHKA — MAPK10

Text-mined interactions from Literome

Zagozdzon et al., Cell Signal 2006 (MAP Kinase Signaling System) : In this work, we compared the effect of CHK versus Csk on MAPK signaling and elucidated the signaling pathway mediated by CHK leading to the activation of Erk1/2
Yalcin et al., Oncogene 2010 (Neoplasms, Experimental) : Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling
Poehlmann et al., Pathol Res Pract 2010 (Neoplasms) : Importantly, as current evidence also suggests a role of MAPK 's ( mitogen activated protein kinases ) in cell cycle checkpoint control, we describe in this review both the ATR/ATM-Chk1/Chk2 signaling pathways as well as the regulation of cell cycle checkpoints by MAPK 's as molecular mechanisms in DDR, and how their dysfunction is related to cancer development