Gene interactions and pathways from curated databases and text-mining

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KRAS — RPS6KB1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RPS6KB1 → KRAS (increases)
    Evidence: these data suggest that mutant ras maintains constitutive phosphorylation of p70 at Thr389 and Thr421/Ser424. Figure 4B demonstrates, in 1 of 3 separate experiments, that readdition of IL-6 to wild type-expressing cells at day +3 reinduces phosphorylation of p70 on Thr389 and Thr421/Ser424, but has no effect on phosphorylation of Ser411. isoform of rps6kb1 in uniprot has 23 additional N-terminal amino acids--DD