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OSM — RAF1

Text-mined interactions from Literome

Lin et al., Arthritis Rheum 2008 (Arthritis, Experimental...) : In MG-63 cells, EGCG alleviated the OSM induced phosphorylation of Raf-1 at Ser338 but restored the dephosphorylation of Raf-1 at Ser259
Stancato et al., Mol Cell Biol 1997 : Beta interferon and oncostatin M activate Raf-1 and mitogen activated protein kinase through a JAK1 dependent pathway ... In HeLa cells, both IFN-beta and oncostatin M (OSM) stimulated MAPK and Raf-1 enzyme activity, in addition to Stat1 and Stat3 tyrosine phosphorylation ... IFN-beta- and OSM induced Raf-1 activity could be coimmunoprecipitated with either Jak1 or Tyk2 ... The requirement for Jak1 for IFN-beta- and OSM induced activation of Raf-1 was also seen in Jak1-deficient U4A fibrosarcoma cells ... Therefore, it appears that Jak1 is required for Raf-1 activation by both IFN-beta and OSM
Stancato et al., J Biol Chem 1998 : Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor ... To examine whether any of the signaling components that are required for activation of the Jak/Stat pathway are also necessary for activation of Raf-1 by IFNs and OSM , we examined activation of Raf-1 in cell lines that are deficient in either Stat1alpha or Stat2