Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of KAT2B-STAT3
→
IL6
(increases)
Ray et al., Mol Endocrinol 2002* Evidence: The observation that IL-6 stimulation increases histone H4 acetylation of the endogenous hAGT promoter, and expression of p300 deficient in histone acetyltransferase activity down-regulates hAGT promoter activity both suggest that p300 histone acetyltransferase activity is required for hAGT expression. Finally, treatment of HepG2 cells with a histone deacetylase inhibitor increased the hAGT mRNA abundance by 2- to 3-fold.