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NEUROD6 — REST

Text-mined interactions from Literome

Immaneni et al., Nucleic Acids Res 2000 : REST-VP16 activates multiple neuronal differentiation genes in human NT2 cells ... However, REST/NRSF ( -/- ) mice suggest that the absence of REST/NRSF dependent repression alone is not sufficient for the expression of these neuronal differentiation genes and that the presence of other promoter/enhancer-specific activators is required
Watanabe et al., Genes Dev 2004 : Here we show that the expression of REST-VP16 in myoblasts grown under muscle differentiation conditions blocked entry into the muscle differentiation pathway, countered endogenous REST/NRSF dependent repression, activated the REST/NRSF target genes, and, surprisingly, activated other neuronal differentiation genes and converted the myoblasts to a physiologically active neuronal phenotype
Su et al., Mol Cell Biol 2004 (Calcium Signaling) : Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation ... These results showed that direct activation of REST/NRSF target genes in NSCs with a single transgene, REST-VP16, is sufficient to cause neuronal differentiation , and the findings suggested that direct activation of genes involved in the terminal stage of differentiation may cause neuronal differentiation of NSCs
Salani et al., J Neurochem 2009 (Brain Neoplasms...) : Acetylcholine induced neuronal differentiation : muscarinic receptor activation regulates EGR-1 and REST expression in neuroblastoma cells