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IL12B — IRF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Coccia et al., J Biol Chem 1999
:
No significant differences of IRF-1 mRNA expression were found in established Th1 and Th2 cells ; however,
interleukin 12 (IL-12) induced a strong up-regulation of
IRF-1 transcripts in Th1 but not in Th2 cells ... We demonstrate that
IL-12 induced up-regulation of
IRF-1 is mediated by signal transducer and activator of transcription-4, which binds to the interferon (IFN)-gamma activated sequence present in the promoter of the IRF-1 gene ... Strong IL-12 dependent activation of a reporter gene construct containing the IRF-1 IFN-gamma activated sequence element provides further evidence for the key role of signal transducer and activator of transcription-4 in the
IL-12 induced up-regulation of
IRF-1 transcripts in T cells
Galon et al., J Immunol 1999
:
IL-12 induces
IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells ... Furthermore, IL-2 and
IL-12 synergistically
induced IRF-1 , whereas IFN-alpha and IL-12 did not ... In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4 stimulated cells, and IL-4 did not block
IL-12 dependent up-regulation of
IRF-1
Masumi et al., FEBS Lett 2002
:
IRF-8/ICSBP and
IRF-1 cooperatively
stimulate mouse
IL-12 promoter activity in macrophages ... Together, these results indicate that ICSBP and
IRF-1 cooperatively
stimulate murine
IL-12 transcription through a novel regulatory element in the murine promoter
Liu et al., J Exp Med 2003
:
IRF-1 plays a major role in the transcriptional activation of the
IL-12 p35 gene, but not of the p40 gene, by physically interacting with an inverted IRF element within the IL-12 p35 promoter upon IFN-gamma activation ... Thus,
IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of
IL-12 p35 transcription in synergy with LPS mediated events ... Thus,
IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of
IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003
:
IFN-alpha and
IL-12 activate
IFN regulatory factor 1 (IRF-1) , IRF-4, and IRF-8 gene expression in human NK and T cells ... Both IFN-alpha and
IL-12 strongly
up-regulated IRF-1,
IRF-4 , and IRF-8 mRNA and protein expression ... Both IFN-alpha and
IL-12 strongly
up-regulated IRF-1 , IRF-4, and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005
:
Furthermore,
IRF-8 induced
IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
Kano et al., Nat Immunol 2008
:
Notably, the
IRF1 dependent induction of IL-12Rbeta1 was
essential for
IFN-gamma-IL-12 signaling but was dispensable for IL-23-IL-17 signaling
Antonios et al., J Immunol 2010
(MAP Kinase Signaling System) :
Our results showed that p38 MAPK, NF-kappaB, and
IRF-1 were
involved in
IL-12p40 production induced by NiSO ( 4 )