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GJA1 — RAC1

Text-mined interactions from Literome

Matsuda et al., J Mol Cell Cardiol 2006 : Furthermore, the translocation of Cx43 to longitudinal cell termini was prevented by the inhibition of Rac1 , but not RhoA
Adam et al., J Am Coll Cardiol 2010 (Atrial Fibrillation...) : In neonatal rat cardiomyocytes and fibroblasts, a specific small molecule inhibitor of Rac1 or simvastatin completely prevented the angiotensin II-induced up-regulation of CTGF, Cx43 , and N-cadherin expression ... Angiotensin II activates CTGF via activation of Rac1 and nicotinamide adenine dinucleotide phosphate oxidase, leading to up-regulation of Cx43 , N-cadherin, and interstitial fibrosis and therefore contributing to the signal transduction of atrial structural remodeling