◀ Back to NOTCH4

ITCH — NOTCH4

Text-mined interactions from Literome

Matesic et al., Hum Mol Genet 2006 (Autoimmune Diseases...) : Since Notch proteins have many important functions in the immune system, we determined whether Itch regulates Notch signaling in vivo
Chastagner et al., PloS one 2008 : AIP4/Itch regulates Notch receptor degradation in the absence of ligand ... Using Itch-/- fibroblasts expressing the Notch1 receptor, we show that Itch is not necessary for Notch activation, but rather for controlling the degradation of Notch in the absence of ligand