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IL6 — NGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → NGF (increases)
  Evidence: While many genes were increased, and fewer decreased, following NGF or BDNF exposure, with a cut-off of 3 fold-change compared to untreated controls, Fibroblast Growth Factor-2 (FGF2) and IL-6 emerged as those genes markedly upregulated following NGF or BDNF treatment in this panel (Figure 3A–B).

Text-mined interactions from Literome

Marshall et al., J Immunol 1999 : We have observed that NGF at doses as low as 10 ng/ml will induce IL-6 production and inhibit TNF-alpha release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor
März et al., Glia 1999 : In addition, we find that Hyper-IL-6 induces expression of neurotrophins (NTs) of the nerve growth factor (NGF)-family in a dose dependent manner
Lipnik-Stanglj et al., Pflugers Arch 2000 : The effects of histamine and interleukin-6 on NGF release from cortical astrocytes in primary culture ... IL-6 antibody effectively blocked the IL-6 stimulatory effect on NGF release, but did not influence NGF release, evoked by histamine
Screpanti et al., Proc Natl Acad Sci U S A 1992 : Finally, we found that IL-6 gene expression in these cell cultures was enhanced by NGF
Jelaso et al., Int J Dev Neurosci 2005 : In the mammalian nervous system, the cytokine, interleukin-1beta (IL-1beta) induces expression of NGF
Jiang et al., J Immunol 2007 : NGF could markedly promote LPS induced expression of HLA-DR, CD40, CD80, CD83, CD86, CCR7, secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6 , TNF-alpha, and the T cell stimulating capacity of MoDCs, indicating that NGF can promote LPS induced DC maturation
Marianecci et al., J Control Release 2010 : The treatment of HLF cells with BDP loaded non-ionic surfactant vesicles determined a noticeable increase of the drug anti-inflammatory activity by reducing the secretion of both constitutive and interleukin-1ß stimulated nerve growth factor ( as inflammatory index ) of 68 % and 85 %, respectively
Varilek et al., Am J Physiol 1995 : Caco-2 monolayers primarily secreted NGF from the basolateral compartment, and interleukin-1 enhanced its secretion
Liebl et al., Biochem Biophys Res Commun 1993 : The binding of TGF-alpha, TGF-beta 1, CNTF, and IL-6 is severely blocked by cationic proteins/NGF
Pshenichkin et al., J Neurochem 1994 : Transcriptional and posttranscriptional mechanisms involved in the interleukin-1 , steroid, and protein kinase C regulation of nerve growth factor in cortical astrocytes
Wu et al., J Biol Chem 1996 : Mechanistically, NGF and bFGF induce a sustained phosphorylation and activation of ERK1 and ERK2 in both cells, while IL-6 produces only a transient and weak tyrosine phosphorylation
Wu et al., J Biol Chem 1996 : With PC12-E2 cells, a subthreshold concentration of IL-6 increases NGF response by approximately 2-3-fold after 1-2 days ; the increase with EGF is more pronounced ... In contrast, NGF and EGF, in the presence or absence of IL-6 , cause mobility shifts of Stat3 that are consistent with serine phosphorylations
Kossmann et al., Brain Res 1996 (Brain Injuries...) : Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes ... The CSF of 8 patients containing IL-6 induced NGF production in astrocytes, whereas control CSF without IL-6 had no effect
Stéphan et al., Mol Cell Endocrinol 1997 : FSH ( 1 x 10 ( -2 ) -1 microg/ml ) and NGF ( 25-200 ug/ml ) stimulated Sertoli cell IL-6 levels in a dose dependent manner but had no effect on IL-1