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BRK1 — RAC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: RAC1 → BRK1 (reaction) Suetsugu et al., J Cell Biol 2006, Miki et al., EMBO J 1998
• Reactome Reaction: RAC1 → BRK1 (indirect_complex) Leng et al., Proc Natl Acad Sci U S A 2005, Suetsugu et al., J Cell Biol 2006, Nakanishi et al., J Biochem 2007, Mendoza et al., Mol Cell 2011, Miki et al., EMBO J 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of ABI2-RAC1-BRK1-CYFIP1-WASF1-NCKAP1 (pull down) Ismail et al., Nature structural & molecular biology 2009
• IRef Dip Interaction: RAC1 — BRK1 (physical association, pull down) Ismail et al., Nature structural & molecular biology 2009
• IRef Hprd Interaction: Complex of 51 proteins (in vivo) Eden et al., Nature 2002, Mayne et al., Eur J Immunol 2004*, Witke et al., EMBO J 1998

Text-mined interactions from Literome

Miki et al., Biochem Biophys Res Commun 2002 : Interestingly, the intramolecular interaction is interrupted by the binding of WAVE2 and full-length IRSp53 associates with Rac in the presence of WAVE2
Oikawa et al., Nat Cell Biol 2004 : Production of PtdIns ( 3,4,5 ) P ( 3 ) at the cell membrane by myristoylated phosphatidylinositol-3-OH kinase ( PI(3)K ) is sufficient to recruit WAVE2 in the presence of dominant negative Rac and latrunculin, demonstrating that PtdIns ( 3,4,5 ) P ( 3 ) alone is able to recruit WAVE2
Suetsugu et al., J Cell Biol 2006 : Purified WAVE2 and purified WAVE2 complex were activated by IRSp53 in a Rac dependent manner with PIP ( 3 ) -containing liposomes ... Therefore, IRSp53 optimizes the activity of the WAVE2 complex in the presence of activated Rac and PIP ( 3 )
Harmon et al., PLoS Pathog 2010 (Astrocytoma...) : Rac and the tyrosine kinase Abl then activate the Wave2 complex and promote Arp2/3 dependent actin polymerization