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FOXP3 — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Grant et al., PLoS Pathog 2006
:
Overexpression of
Foxp3 in HEK 293T and purified CD4+ T cells
resulted in a dose dependent and time dependent decrease in basal levels of
nuclear factor-kappaB (NF-kappaB) activation ... These results suggest an expanded
role for
Foxp3 in regulating
NF-kappaB- and CREB dependent cellular and viral gene expression
Holmes et al., J Biol Chem 2007
:
Although NFkappaB nuclear translocation is not altered,
FoxP3 enhances
NFkappaB-p65 binding to HIV-1 LTR
Krejsgaard et al., Leukemia 2008
(Sezary Syndrome...) :
In contrast to wt FOXP3, the low molecular splice forms of
FOXP3 have no inhibitory
effect on
nuclear factor-kappaB (NF-kappaB) activity in reporter assays which is in keeping with a constitutive NF-kappaB activity in the malignant T cells
Long et al., Immunity 2009
:
NF-kappaB directly
promoted the transcription of
Foxp3 , and upon T cell receptor ( TCR ) stimulation, c-Rel, a NF-kappaB family member, bound to Foxp3 enhancer region, which is specifically demethylated in natural Treg cells