Pigazzi et al., J Biol Chem 1999
:
The activation of LYN associated PI3-kinase was unrelated to changes in the amount of PI3-kinase physically associated with LYN signaling complexes but did require the activation of LYN and other tyrosine kinases
Ptasznik et al., J Exp Med 2002
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
We show that the binding of phosphorylated BCR/ABL to Lyn results in the constitutive activation of Lyn and PI3-kinase , along with a total loss of responsiveness of these kinases to SDF-1 stimulation
Boudot et al., Biochem Biophys Res Commun 2003
:
We examined the role of the Src kinase Lyn in phospholipase C-gamma 2 ( PLC-gamma 2 ) and phosphatidylinositol (PI) 3-kinase activation in erythropoietin (Epo) stimulated FDC-P1 cells transfected with a wild type ( WT ) Epo-receptor (Epo-R) ... Our results suggest that the Src kinase Lyn is involved in PLC-gamma 2 phosphorylation and PI 3-kinase activation induced by Epo