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ANGPT2 — EGR1

Text-mined interactions from Literome

Deguchi et al., Circ Res 1999 : In adult rat VSMCs, Ang II activates ERK and JNK, but weakly induces Egr-1 , a transcription factor implicated in PDGF-B chain gene expression, compared with newborn VSMCs
Sachinidis et al., FEBS Lett 1992 : Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively
Pulver-Kaste et al., Am J Physiol Heart Circ Physiol 2006 (Calcium Signaling) : The physiological agonist ANG II also stimulated expression of Egr-1 and MKP-1
Iwami et al., Am J Physiol 1996 : ANG II treatment ( 10 ( -10 ) -10 ( -6 ) M ) of rat cardiac fibroblasts induced 1 ) Egr-1 and 2 ) a fourfold ( P < 0.02 ) increase in fibronectin and a twofold ( P = 0.05 ) increase in laminin mRNA levels but no increases in that of collagens I, III, or IV at 24-48 h, and 3 ) a decrease in AT1-receptor mRNA levels to 26 % ( P < 0.001 ) of basal at 4-6 h
McKay et al., Am J Respir Cell Mol Biol 1998 (Hyperplasia...) : We studied the effects of Ang II on ASM cell proliferation and growth and on the expression of three transcription factors, egr-1 , c-fos, and c-jun, as well as a cytokine, transforming growth factor-beta1 ( TGF-beta1 ) ... Ang II stimulated the expression of egr-1 and c-fos as early as 15 min, reaching maximum levels at 45 min, whereas the expression of c-jun peaked at 2 h of Ang II exposure